Jolkkonen J, Helkala E L, Kutvonen R, Lehtinen M, Riekkinen P J
Department of Neurology, University of Kuopio, Finland.
Psychoneuroendocrinology. 1989;14(1-2):89-95. doi: 10.1016/0306-4530(89)90057-7.
Concentrations of vasopressin (AVP) and monoamine metabolites (HVA, 5-HIAA, MHPG) in cerebrospinal fluid (CSF) were measured and compared with memory functions in patients with dementia of Alzheimer type (DAT) and control subjects. CSF concentrations did not differ between the DAT patients and the controls, or between patients with different degrees of dementia. There were no correlations between concentrations of vasopressin and monoamine metabolites in CSF or between the CSF measures and psychological test scores, except for a correlation between CSF HVA and immediate and delayed story recall. These data suggest that probable damage to the vasopressinergic and monoaminergic systems in DAT is not reflected in the CSF of patients in early stages of the disease, nor is a deficit in these systems or their interaction the primary cause of cognitive impairment in DAT.
对阿尔茨海默型痴呆（DAT）患者和对照受试者的脑脊液（CSF）中血管加压素（AVP）和单胺代谢产物（高香草酸、5-羟吲哚乙酸、3-甲氧基-4-羟基苯乙二醇）的浓度进行了测量，并与记忆功能进行了比较。DAT患者与对照组之间，以及不同痴呆程度的患者之间，脑脊液浓度并无差异。脑脊液中血管加压素和单胺代谢产物的浓度之间，以及脑脊液测量值与心理测试分数之间均无相关性，但脑脊液高香草酸与即时和延迟故事回忆之间存在相关性。这些数据表明，DAT中血管加压素能和单胺能系统可能的损伤在疾病早期患者的脑脊液中并未体现，这些系统的缺陷或它们之间的相互作用也不是DAT认知障碍的主要原因。
