Blennow K, Wallin A, Gottfries C G, Lekman A, Karlsson I, Skoog I, Svennerholm L
Department of Psychiatry and Neurochemistry, Gothenburg University, St. Jörgen's Hospital Hisings Backa, Sweden.
Neurobiol Aging. 1992 Jan-Feb;13(1):107-13. doi: 10.1016/0197-4580(92)90017-r.
The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a wide variability in values among both patients and controls was found, as well as fluctuations in repeated samples from individual patients. This suggests that several unknown factors influence the lumbar CSF levels of monoamine metabolites. The AD group showed significantly lower mean levels of HVA (p less than 0.0001) and 5-HIAA (p less than 0.0001) than the control group. A relation between severity of disease and HVA was also found. The widespread neurotransmitter disturbance in AD, together with the nonspecificity of reduced lumbar HVA and 5-HIAA levels, suggests that the changes are nonspecific, secondary to the cerebral degeneration in AD.
在123例阿尔茨海默病（AD）患者和57名健康对照者的腰椎脑脊液（CSF）中测定了单胺代谢产物高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和4-羟基-3-甲氧基苯乙二醇（HMPG）。尽管在严格标准化条件下采集脑脊液，但患者和对照者的值均存在很大差异，而且个体患者的重复样本也有波动。这表明有几个未知因素影响腰椎脑脊液中单胺代谢产物的水平。AD组的HVA平均水平（p<0.0001）和5-HIAA平均水平（p<0.0001）显著低于对照组。还发现疾病严重程度与HVA之间存在关联。AD中广泛存在的神经递质紊乱，以及腰椎HVA和5-HIAA水平降低的非特异性，表明这些变化是非特异性的，继发于AD中的脑变性。
