贝加尔乌头中二萜生物碱的抗炎活性
Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense.
作者信息
Nesterova Yu V, Povetieva T N, Suslov N I, Zyuz'kov G N, Aksinenko S G, Pushkarskii S V, Krapivin A V
机构信息
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia,
出版信息
Bull Exp Biol Med. 2014 Mar;156(5):665-8. doi: 10.1007/s10517-014-2421-4. Epub 2014 Mar 30.
We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.
我们比较了从贝加尔乌头中分离出的单一二萜生物碱（那可汀、宋果灵、次乌头碱、新乌头碱、12-表那可汀N-氧化物）在不同成因急性炎症条件下的抗炎活性。受试物质显示出与双氯芬酸钠相当的高抗渗出活性。与非甾体抗炎药不同，二萜生物碱没有致溃疡作用。
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