Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Nanoscale. 2014 Aug 21;6(16):9421-7. doi: 10.1039/c4nr00340c. Epub 2014 Apr 28.
Rosette nanotubes are biologically inspired nanostructures, formed through the hierarchical organization of a hybrid DNA base analogue (G∧C), which features hydrogen-bonding arrays of guanine and cytosine. Several twin-G∧C motifs functionalized with chiral moieties, which undergo a self-assembly process under methanolic and aqueous conditions to produce helical rosette nanotubes (RNTs), were synthesized and characterized. The built-in molecular chirality in the twin-G∧C building blocks led to the supramolecular chirality exhibited by the RNTs, as evidenced by the CD activity. Depending on the motifs and environmental conditions, mirror-image supramolecular chirality due to absolute molecular chirality, solvent-induced and structure-dependent supramolecular chirality inversion, and pH-controlled chiroptical switching were observed.
蔷薇纳米管是受生物启发的纳米结构，通过杂交 DNA 碱基类似物（G∧C）的分级组织形成，其特征是具有氢键阵列的鸟嘌呤和胞嘧啶。几个双 G∧C 基序用手性部分功能化，在手性部分的作用下，在甲醇和水条件下进行自组装过程，产生螺旋蔷薇纳米管（RNTs），然后对其进行合成和表征。双 G∧C 构建块中的内置分子手性导致 RNTs 表现出超分子手性，这可以通过 CD 活性来证明。根据基序和环境条件，可以观察到由于绝对分子手性、溶剂诱导和结构依赖性超分子手性反转以及 pH 控制的手性开关而导致的镜像超分子手性。
