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经皮酒精注射蝶腭神经节治疗顽固性颅面部疼痛

Alcohol percutaneous neurolysis of the sphenopalatine ganglion in the management of refractory cranio-facial pain.

作者信息

Kastler Adrian, Cadel Gilles, Comte Alexandre, Gory Guillaume, Piccand Veronique, Tavernier Laurent, Kastler Bruno

机构信息

Neuroradiology Department, Grenoble University Hospital, Grenoble, France,

出版信息

Neuroradiology. 2014 Jul;56(7):589-96. doi: 10.1007/s00234-014-1354-y. Epub 2014 Apr 26.

Abstract

INTRODUCTION

The sphenopalatine ganglion (SPN) has been proven to be involved in various types of facial pain syndromes. Management of these cranio-facial pain syndromes can be challenging, and existing specific treatments are sometimes inefficient and may fail. The purpose of this study is to describe and evaluate alcohol SPN in the management of cranio-facial pain.

METHODS

Forty-two patients suffering from refractory facial pain who underwent 58 consecutive SPN were included in this study between 2000 and 2013. Patients were divided into three groups: group "cluster headache" (CH), group "persistent idiopathic facial pain" (PFIP), and group "Other". Pain was assessed using Visual Analogue Scale scores (measured immediately before and after procedure and at regular intervals following the procedure). Alcohol SPN was considered to be effective when pain relief was equal to or greater than 50 % and lasting for at least 1 month. All procedures were realized ambulatory under CT guidance and consisted of an injection of 1 ml of absolute alcohol.

RESULTS

Overall efficacy rate of alcohol SPN was 67.2 %, with mean pain relief duration of 10.3 months. Procedure was graded either not painful or tolerable by patients in 64.2 %. Analysis showed a higher efficacy rate in the groups CH (76.5 %) and PFIP (85.7 %) compared to the group Other (40 %). No difference was found between groups regarding the recurrence rate.

CONCLUSION

Alcohol SPN under CT guidance appears as a safe and effective treatment of refractory facial pain, especially in cases of cluster headache and persistent idiopathic facial pain.

摘要

引言

蝶腭神经节(SPN)已被证明与多种类型的面部疼痛综合征有关。这些颅面部疼痛综合征的治疗具有挑战性,现有的特定治疗方法有时效果不佳且可能失败。本研究的目的是描述和评估酒精注射蝶腭神经节在颅面部疼痛治疗中的应用。

方法

2000年至2013年期间,42例患有难治性面部疼痛且连续接受58次蝶腭神经节治疗的患者纳入本研究。患者分为三组:“丛集性头痛”(CH)组、“持续性特发性面部疼痛”(PFIP)组和“其他”组。使用视觉模拟量表评分评估疼痛(在治疗前、治疗后立即以及治疗后定期测量)。当疼痛缓解等于或大于50%且持续至少1个月时,酒精注射蝶腭神经节被认为有效。所有操作均在CT引导下门诊进行,包括注射1毫升无水酒精。

结果

酒精注射蝶腭神经节的总体有效率为67.2%,平均疼痛缓解持续时间为10.3个月。64.2%的患者将该操作评为无痛或可耐受。分析显示,CH组(76.5%)和PFIP组(85.7%)的有效率高于“其他”组(40%)。各组之间复发率无差异。

结论

CT引导下酒精注射蝶腭神经节似乎是一种安全有效的难治性面部疼痛治疗方法,尤其是在丛集性头痛和持续性特发性面部疼痛的病例中。

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