Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Gastric Cancer. 2015 Apr;18(2):246-55. doi: 10.1007/s10120-014-0376-9. Epub 2014 Apr 27.
Gastric lymphoepithelioma-like carcinoma (LELC) is a rare entity that is closely associated with Epstein-Barr virus (EBV). However, the EBV latency pattern and genome polymorphisms in gastric LELC have not been systematically explored.
The clinicopathological features, EBV latency pattern and genome polymorphisms of EBV-positive gastric LELC in Guangzhou, southern China were investigated and compared with those of ordinary EBV-associated gastric carcinoma (EBVaGC) in the same area.
Ten (1.42%) of 702 gastric carcinoma cases were identified as gastric LELC, in which eight (80%) cases were EBV-positive. The clinicopathological characteristics and EBV latency pattern of EBV-positive gastric LELC were similar to those of ordinary EBVaGC. In EBV genotype analysis, type A strain, type F, I, mut-W1/I, XhoI- and del-LMP1 variants were predominant among EBV-positive gastric LELCs, accounting for eight (100%), six (75%), eight (100%), seven (87.5%), five (62.5%) and six (75%) cases, respectively, which are similar to those in ordinary EBVaGC. For EBNA1 polymorphisms, the V-leu and P-ala subtypes were predominant in EBV-positive gastric LELC, which is different from the predominant V-val subtype in ordinary EBVaGC. EBV-positive gastric LELC has a favorable prognosis when compared to ordinary EBVaGC (median survival time 43.0 vs. 18.0 months).
Gastric LELC is strongly associated with EBV and EBV-positive gastric LELC should be regarded as a special subtype of EBVaGC. This, to our best knowledge, is the first time in the world that the EBV latency pattern and genome polymorphisms of EBV-positive gastric LELC are systematically revealed.
胃淋巴上皮样癌（LELC）是一种罕见的实体瘤，与 Epstein-Barr 病毒（EBV）密切相关。然而，胃 LELC 中的 EBV 潜伏期模式和基因组多态性尚未得到系统探索。
本研究调查并比较了中国南方广州地区 EBV 阳性胃 LELC 的临床病理特征、EBV 潜伏期模式和基因组多态性，以及同一地区的普通 EBV 相关胃癌（EBVaGC）。
在 702 例胃癌病例中，发现 10 例（1.42%）为胃 LELC，其中 8 例（80%）为 EBV 阳性。EBV 阳性胃 LELC 的临床病理特征和 EBV 潜伏期模式与普通 EBVaGC 相似。在 EBV 基因型分析中，A型株、F 型、I 型、mut-W1/I 型、XhoI-型和 del-LMP1 变异型在 EBV 阳性胃 LELC 中占主导地位，分别占 8 例（100%）、6 例（75%）、8 例（100%）、7 例（87.5%）、5 例（62.5%）和 6 例（75%），与普通 EBVaGC 相似。对于 EBNA1 多态性，在 EBV 阳性胃 LELC 中，V-leu 和 P-ala 亚型占主导地位，与普通 EBVaGC 中主要的 V-val 亚型不同。与普通 EBVaGC 相比，EBV 阳性胃 LELC 的预后较好（中位生存时间 43.0 与 18.0 个月）。
胃 LELC 与 EBV 密切相关，EBV 阳性胃 LELC 应视为 EBVaGC 的一种特殊亚型。据我们所知，这是首次系统揭示 EBV 阳性胃 LELC 的 EBV 潜伏期模式和基因组多态性。
