与两种催化伙伴结合的酰基载体蛋白的晶体结构在细胞代谢中显示出动态作用。
Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism.
作者信息
Newmister Sean A, Sherman David H
机构信息
Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA).
出版信息
Chembiochem. 2014 May 26;15(8):1079-81. doi: 10.1002/cbic.201402095. Epub 2014 Apr 25.
Abstract
ACP captured in action: Two recently reported crystal structures are the first to capture ACP-mediated substrate delivery to a catalytic partner at high resolution. These studies highlight key interactions of transient ACP-partner complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.
摘要
在实际操作中捕获的酰基载体蛋白（ACP）：最近报道的两个晶体结构首次在高分辨率下捕获了ACP介导的底物向催化伙伴的传递。这些研究突出了瞬时ACP-伙伴复合物的关键相互作用，并确定了促进底物传递和触发复合物解离的ACP的动态运动。
相似文献
1
Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism.
Chembiochem. 2014 May 26;15(8):1079-81. doi: 10.1002/cbic.201402095. Epub 2014 Apr 25.
2
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature. 2014 Jan 16;505(7483):427-31. doi: 10.1038/nature12810. Epub 2013 Dec 22.
3
Structural and dynamical rationale for fatty acid unsaturation in .
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6775-6783. doi: 10.1073/pnas.1818686116. Epub 2019 Mar 14.
4
Molecular basis for interactions between an acyl carrier protein and a ketosynthase.
Nat Chem Biol. 2019 Jul;15(7):669-671. doi: 10.1038/s41589-019-0301-y. Epub 2019 Jun 17.
5
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem. 2005;74:791-831. doi: 10.1146/annurev.biochem.74.082803.133524.
6
The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal.
Biochem J. 2014 Jun 1;460(2):157-63. doi: 10.1042/BJ20140239.
7
Structure, High Affinity, and Negative Cooperativity of the Escherichia coli Holo-(Acyl Carrier Protein):Holo-(Acyl Carrier Protein) Synthase Complex.
J Mol Biol. 2017 Nov 24;429(23):3763-3775. doi: 10.1016/j.jmb.2017.10.015. Epub 2017 Oct 18.
8
Structure and dynamics of human and bacterial acyl carrier proteins and their interactions with fatty acid synthesis proteins.
Biochem Biophys Res Commun. 2019 Sep 3;516(4):1183-1189. doi: 10.1016/j.bbrc.2019.07.018. Epub 2019 Jul 8.
9
Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature. 2014 Jan 16;505(7483):422-6. doi: 10.1038/nature12679. Epub 2013 Nov 6.
10
Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.
J Biol Chem. 2014 May 30;289(22):15527-35. doi: 10.1074/jbc.M114.564278. Epub 2014 Apr 16.
本文引用的文献
1
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature. 2014 Jan 16;505(7483):427-31. doi: 10.1038/nature12810. Epub 2013 Dec 22.
2
Chasing acyl carrier protein through a catalytic cycle of lipid A production.
Nature. 2014 Jan 16;505(7483):422-6. doi: 10.1038/nature12679. Epub 2013 Nov 6.
3
The structural role of the carrier protein--active controller or passive carrier.
Nat Prod Rep. 2012 Oct;29(10):1111-37. doi: 10.1039/c2np20062g. Epub 2012 Aug 24.
4
Dehydratase-specific probes for fatty acid and polyketide synthases.
J Am Chem Soc. 2012 Jan 18;134(2):769-72. doi: 10.1021/ja2082334. Epub 2011 Dec 29.
5
Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis.
Biochemistry. 2009 Sep 15;48(36):8672-83. doi: 10.1021/bi901025v.
6
In vivo functional analyses of the type II acyl carrier proteins of fatty acid biosynthesis.
J Biol Chem. 2007 Jul 13;282(28):20319-28. doi: 10.1074/jbc.M703789200. Epub 2007 May 23.
7
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase.
Science. 2007 Apr 13;316(5822):288-90. doi: 10.1126/science.1138249.
8
Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis.
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4321-6. doi: 10.1073/pnas.0606356104. Epub 2007 Mar 5.
9
Beta-hydroxydecanoyl thioester dehydrase. Studies on molecular structure and active site.
J Biol Chem. 1969 Nov 10;244(21):6014-22.
10
On the enzymatic synthesis of unsaturated fatty acids in Escherichia coli.
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1168-73. doi: 10.1073/pnas.58.3.1168.
Zotero 插件