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阿尔茨海默病中滑面内质网的积累：轴浆流紊乱的新形态学证据。

Accumulation of smooth endoplasmic reticulum in Alzheimer's disease: new morphological evidence of axoplasmic flow disturbances.

作者信息

Richard S, Brion J P, Couck A M, Flament-Durand J

机构信息

Laboratoire de Pathologie, Hôpital Necker-Enfants Malades, Paris, France.

出版信息

J Submicrosc Cytol Pathol. 1989 Jul;21(3):461-7.

PMID:2477140
Abstract

Numerous enlarged neurites and presynaptic terminals containing tubulovesicular profiles of smooth endoplasmic reticulum (SER) were observed in frontal biopsies from six patients with Alzheimer's disease. These accumulations of SER probably reflect disturbances of axoplasmic flows. In addition, curvilinear tubular inclusions similar to those characteristic of Farber's disease were found in one patient. Finally, accumulation of glycogen within neurites and enlarged mitochondria were observed in all patients.

摘要

在6例阿尔茨海默病患者的额叶活检中，观察到大量增大的神经突和含有光滑内质网（SER）管状小泡轮廓的突触前终末。SER的这些积聚可能反映了轴浆流的紊乱。此外，在1例患者中发现了与法伯病特征相似的曲线形管状包涵体。最后，在所有患者中均观察到神经突内糖原积聚和线粒体增大。

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