Sloper J J, Barnard R O, Eglin R P, Powell T P
Neuropathol Appl Neurobiol. 1986 Sep-Oct;12(5):491-501. doi: 10.1111/j.1365-2990.1986.tb00057.x.
The electron microscope has been used to examine a diagnostic biopsy of frontal neocortex which showed the light microscopic features of Alzheimer's disease. In addition to plaques and tangles, the biopsy showed some neurons which contained abnormal tubular profiles specifically associated with their granular endoplasmic reticulum. In transverse section the profiles consisted of two concentric layers of trilaminar unit membrane with an overall diameter of approximately 75 nm and they appeared to lie within the cisternae of granular endoplasmic reticulum. When cut longitudinally, the structures appeared as elongated tubes lying within the endoplasmic reticulum, but a number of ends were found where the inner membrane formed a closed tube and the outer membrane folded back and was continuous with the membrane forming the outer layer of the sac of endoplasmic reticulum. These profiles do not appear to have been described previously although similarities between their ultrastructure and that of the coat of certain unusual forms of Rhabdovirus are noted.
电子显微镜已被用于检查额叶新皮质的诊断性活检组织，该组织呈现出阿尔茨海默病的光学显微镜特征。除了斑块和缠结外，活检组织还显示出一些神经元，这些神经元含有与其颗粒内质网特异性相关的异常管状结构。在横切面上，这些结构由两层同心的三层单位膜组成，总直径约为75纳米，它们似乎位于颗粒内质网的池内。纵向切割时，这些结构呈现为位于内质网内的细长管，但发现许多末端，其中内膜形成一个封闭的管，外膜折回并与形成内质网囊外层的膜连续。尽管注意到它们的超微结构与某些不寻常形式的弹状病毒包膜的超微结构有相似之处，但这些结构似乎以前没有被描述过。
