下一代药物洗脱支架时代的双联抗血小板治疗持续时间
Duration of dual antiplatelet treatment in the era of next generation drug-eluting stents.
作者信息
Rha Seung-Woon
机构信息
Seung-Woon Rha, Cardiovascular Center, Korea University Guro Hospital, Seoul 152-703, South Korea.
出版信息
World J Cardiol. 2014 Apr 26;6(4):148-53. doi: 10.4330/wjc.v6.i4.148.
Abstract
Current percutaneous coronary intervention guidelines recommend dual antiplatelets (aspirin 100 mg + clopidogrel 75 mg daily) for at least 12 mo following drug-eluting stent (DES) implantation if patients are not at high risk of bleeding. Several reports have tried to shorten the dual antiplatelet therapy to 3-6 mo, especially following next-generation DES implantation, for cost-effectiveness. However, the clinical results are inconsistent and the data regarding next-generation DESs limited. In this report, recently published important pivotal reports regarding the optimal duration of dual antiplatelets following DES implantation are summarized.
摘要
目前的经皮冠状动脉介入治疗指南建议，如果患者没有高出血风险，在药物洗脱支架（DES）植入后至少12个月给予双联抗血小板治疗（阿司匹林100毫克+氯吡格雷75毫克每日）。一些报告试图将双联抗血小板治疗缩短至3 - 6个月，特别是在植入新一代DES后，以提高成本效益。然而，临床结果并不一致，且关于新一代DES的数据有限。在本报告中，总结了最近发表的关于DES植入后双联抗血小板最佳疗程的重要关键报告。
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