Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305, CNRS - Université Lyon 1, Institut de Biologie et Chimie des Protéines, SFR BioSciences Gerland-Lyon Sud, 7 passage du Vercors, F-69367, France.
Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305, CNRS - Université Lyon 1, Institut de Biologie et Chimie des Protéines, SFR BioSciences Gerland-Lyon Sud, 7 passage du Vercors, F-69367, France.
Matrix Biol. 2019 Jan;75-76:12-26. doi: 10.1016/j.matbio.2018.01.002. Epub 2018 Jan 10.
The ability of skin to act as a barrier is primarily determined by cells that maintain the continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult mammals is a complex multi-step process that involves overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodeling. Under favorable conditions, epidermal regeneration begins within hours after injury and takes several days until the epithelial surface is intact due to reorganization of the basement membrane. Regeneration relies on numerous signaling cues and on multiple cellular processes that take place both within the epidermis and in other participating tissues. A variety of modulators are involved, including growth factors, cytokines, matrix metalloproteinases, cellular receptors, and extracellular matrix components. Here we focus on the involvement of the extracellular matrix proteins that impact epidermal regeneration during wound healing.
皮肤作为屏障的能力主要取决于维持皮肤连续性和完整性并在损伤后进行修复的细胞。成年哺乳动物的皮肤创伤愈合是一个复杂的多步骤过程，涉及到血栓形成、炎症、再上皮化、肉芽组织形成、血管新生和重塑的重叠阶段。在有利条件下，表皮再生在损伤后数小时内开始，并需要几天时间，直到由于基底膜的重组，上皮表面完整。再生依赖于许多信号线索和发生在表皮内和其他参与组织中的多种细胞过程。多种调节剂参与其中，包括生长因子、细胞因子、基质金属蛋白酶、细胞受体和细胞外基质成分。在这里，我们重点关注在创伤愈合过程中影响表皮再生的细胞外基质蛋白的参与。
