Muñoz-Torres Jose R, Garza-Veloz Idalia, Velasco-Elizondo Perla, Martinez-Fierro Margarita L
Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Zacatecas 98160, Mexico.
Diagnostics (Basel). 2025 Feb 6;15(3):387. doi: 10.3390/diagnostics15030387.
Wounds affect approximately 15 out of every 1000 individuals, representing a significant healthcare challenge. The preclinical evaluation of novel wound treatments is important for advancing therapies that promote effective skin regeneration and improve healing outcomes. In this study, we integrated existing knowledge from the literature on murine wound healing models, histological features of the skin, and clinical scores described in humans to propose two complementary assessment tools: the HEALS-A histological score (healing, epithelialization, angiogenesis, leukocytes, scar tissue, appendages) and the GRADES clinical score (granulation tissue, redness/edema, appearance of wound, devitalized tissue). These scales combine real-time clinical observation with detailed histological analysis, providing a practical and comprehensive approach to assessing wound healing. Unlike existing wound assessing approaches, HEALS-A does not require specialized software and considers regenerated tissue structures, ensuring a broader and more-detailed evaluation. The assessment of wound closure over time, combined with clinical evaluation and histological analysis of skin, provides a comprehensive approach to determining the true impact of new treatments on skin regeneration and the recovery of its functions in wounds.
每1000人中约有15人会受伤，这是一个重大的医疗挑战。新型伤口治疗方法的临床前评估对于推进促进有效皮肤再生和改善愈合结果的疗法至关重要。在本研究中，我们整合了文献中关于小鼠伤口愈合模型、皮肤组织学特征以及人类描述的临床评分的现有知识，提出了两种互补的评估工具：HEALS-A组织学评分（愈合、上皮化、血管生成、白细胞、瘢痕组织、附属器）和GRADES临床评分（肉芽组织、发红/水肿、伤口外观、失活组织）。这些量表将实时临床观察与详细的组织学分析相结合，为评估伤口愈合提供了一种实用且全面的方法。与现有的伤口评估方法不同，HEALS-A不需要专门软件，并考虑了再生组织结构，确保了更广泛、更详细的评估。对伤口随时间的闭合情况进行评估，结合皮肤的临床评估和组织学分析，为确定新治疗方法对皮肤再生及其在伤口中功能恢复的真正影响提供了一种全面的方法。
