Eckes Beate, Krieg Thomas, Wickström Sara A
Dermatology, University of Cologne, Cologne, Germany.
Exp Dermatol. 2014 Jul;23(7):453-6. doi: 10.1111/exd.12429.
Cell-matrix adhesions provide structural stability to the tissue and regulate intracellular signalling pathways that are important for cell fate decisions of the different cell populations within the skin. As a consequence of these central functions, genetic or functional impairment of various key protein components of matrix adhesions plays a causative role in the aetiology or pathophysiology in a large variety of skin disorders. Research towards understanding the molecular composition of these adhesions as well as the mechanisms by which they transmit signals is therefore of obvious importance. In this essay, we discuss the roles of integrin-linked kinase, a key component of cell-matrix adhesions, in the (patho)physiology of skin and in particular highlight its role in regulating mechanical tension and matrix remodelling both in the epidermis and in the dermis.
细胞与基质的黏附为组织提供结构稳定性，并调节细胞内信号通路，这些信号通路对于皮肤内不同细胞群体的细胞命运决定至关重要。由于这些核心功能，基质黏附的各种关键蛋白质成分的遗传或功能损伤在多种皮肤疾病的病因学或病理生理学中起致病作用。因此，研究这些黏附的分子组成以及它们传递信号的机制显然具有重要意义。在本文中，我们讨论了整合素连接激酶（细胞与基质黏附的关键成分）在皮肤（病理）生理学中的作用，尤其强调了其在调节表皮和真皮中的机械张力及基质重塑方面的作用。
