Milićević N M, Milićević Z
Institute of Histology, Medical Faculty, University of Beograd, Yugoslavia.
J Comp Pathol. 1989 Aug;101(2):143-50. doi: 10.1016/0021-9975(89)90062-5.
Young adult male Wistar rats received a single injection of nickel chloride (0.5 mmol per kg) and were killed 72 h later. Histological examination showed that numerous, large, vacuolated cells appeared in the thymic cortex, which was almost totally depleted of lymphocytes. Enzyme histochemistry revealed that these cells were strongly acid phosphatase-positive macrophages. They contained aldehyde fuchsin-positive granules of varying size. Histochemical tests showed that these macrophages contained products of lipid peroxidation. According to the enzyme and histochemical characteristics, the macrophages which appeared in the thymic cortex during nickel-induced acute involution were identical to the special type of macrophage found in the cortico-medullary zone of the normal rat thymus.
年轻成年雄性Wistar大鼠接受单次氯化镍注射（0.5 mmol/kg），72小时后处死。组织学检查显示，胸腺皮质出现大量大的空泡化细胞，淋巴细胞几乎完全耗竭。酶组织化学显示这些细胞为强酸性磷酸酶阳性巨噬细胞。它们含有大小不一的醛复红阳性颗粒。组织化学检测表明这些巨噬细胞含有脂质过氧化产物。根据酶和组织化学特征，镍诱导急性退化过程中出现在胸腺皮质的巨噬细胞与正常大鼠胸腺皮质髓质区发现的特殊类型巨噬细胞相同。
