1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Monterey Spine, Monterey, California, USA.
Nat Methods. 2014 Jun;11(6):670-6. doi: 10.1038/nmeth.2936. Epub 2014 Apr 28.
Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D) multielectrode implants. This approach allowed us to isolate up to 1,800 neurons (units) per animal and simultaneously record the extracellular activity of close to 500 cortical neurons, distributed across multiple cortical areas, in freely behaving rhesus monkeys. The method is expandable, in principle, to thousands of simultaneously recorded channels. It also allows increased recording longevity (5 consecutive years) and recording of a broad range of behaviors, such as social interactions, and BMI paradigms in freely moving primates. We propose that wireless large-scale recordings could have a profound impact on basic primate neurophysiology research while providing a framework for the development and testing of clinically relevant neuroprostheses.
技术的进步有助于记录大规模的大脑活动，这既有助于阐明神经生理学原理，也有助于开发脑机接口 (BMI)。在这里，我们描述了一种基于可移动的容积式三维 (3D) 多电极植入物进行有线和无线大规模记录的神经生理学范例。这种方法允许我们每只动物隔离多达 1800 个神经元（单位），并同时记录近 500 个皮质神经元的细胞外活动，这些神经元分布在多个皮质区域，在自由行为的恒河猴中。该方法原则上可以扩展到数千个同时记录的通道。它还允许增加记录寿命（连续 5 年）和记录广泛的行为，如社交互动和自由移动灵长类动物的 BMI 范例。我们提出，无线大规模记录可能会对基础灵长类神经生理学研究产生深远影响，同时为临床相关神经假体的开发和测试提供框架。
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