一项双盲随机试验表明，益生菌对印度尼西亚儿童的急性腹泻无效。
A double blind randomized trial showing probiotics to be ineffective in acute diarrhea in Indonesian children.
作者信息
Hegar Badriul, Waspada I Made Indra, Gunardi Hartono, Vandenplas Yvan
机构信息
Department of Child Health, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
出版信息
Indian J Pediatr. 2015 May;82(5):410-4. doi: 10.1007/s12098-014-1408-5. Epub 2014 Apr 29.
OBJECTIVE
To investigate the efficacy of probiotics added to oral rehydration solution and zinc in the treatment of acute infectious diarrhea in Indonesian children.
METHODS
A prospective randomized double blind placebo-controlled trial was performed to test the efficacy of a probiotic food supplement in 112 children in the Kenari subdistrict, central Jakarta, aged 6-36 mo with acute infectious diarrhea and moderate dehydration. The supplemented group was given standard therapy (oral rehydration solution and zinc) and the probiotic strains Lactobacillus (L.) rhamnosus R0011 1.9 × 10(9) colony forming units (cfu) and L. acidophilus R0052 0.1 × 10(9) cfu/d for 7 d, while the control group was given standard therapy and placebo.
RESULTS
Median duration of diarrhea was 68.5 h (range 13-165) in the supplemented and 61.5 h (range 21-166) in the control group (P = 0.596). Median daily frequency of defecation until diarrhea stopped was 5.0 in the supplemented vs. 5.5 in the control group (P = 0.795).
CONCLUSIONS
This probiotic food supplement tested did not reduce the duration of acute infectious diarrhea as compared to oral rehydration and zinc.
目的
探讨在口服补液盐和锌中添加益生菌对印度尼西亚儿童急性感染性腹泻的治疗效果。
方法
进行一项前瞻性随机双盲安慰剂对照试验，以测试一种益生菌食品补充剂对雅加达市中心凯纳里分区112名6至36个月大的急性感染性腹泻且有中度脱水的儿童的疗效。补充组给予标准治疗（口服补液盐和锌）以及鼠李糖乳杆菌R0011 1.9×10⁹菌落形成单位（cfu）和嗜酸乳杆菌R0052 0.1×10⁹ cfu/d，持续7天，而对照组给予标准治疗和安慰剂。
结果
补充组腹泻的中位持续时间为68.5小时（范围13 - 165小时），对照组为61.5小时（范围21 - 166小时）（P = 0.596）。腹泻停止前排便的中位每日频率在补充组为5.0次，对照组为5.5次（P = 0.795）。
结论
与口服补液盐和锌相比，所测试的这种益生菌食品补充剂并未缩短急性感染性腹泻的持续时间。
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