Niazi Azfar Khan, Kaley Kristin, Saif Muhammad Wasif
MBBS, Director, Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine and Tufts Cancer Center, 800 Washington Street, Boston, MA 02111, U.S.A.
Anticancer Res. 2014 May;34(5):2547-50.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. GISTs originate from cells of Cajal and related stem cells. Surgery and imatinib therapy are the main lines of treatment.
We report on a case with GIST in the colon treated with surgical resection followed by adjuvant imatinib therapy. This treatment showed no side-effects, and subsequent colonoscopy was unremarkable.
The diagnosis was delayed for 12 months after initial presentation of vague abdominal pain, thus highlighting the need to improve clinical suspicion in order to detect GISTs in earlier stages when resection may be curative. Colonic GIST, in particular, may mimic presentation similar to ovarian cyst, as seen in the present case. This case report corroborates that patients with high-grade GISTs can be effectively treated with imatinib therapy. However, duration of treatment may vary depending on the grade of the tumor and side-effects.
胃肠道间质瘤（GISTs）是胃肠道最常见的间叶性肿瘤。GISTs起源于卡哈尔细胞及相关干细胞。手术和伊马替尼治疗是主要的治疗方法。
我们报告一例结肠GIST患者，接受手术切除并辅助伊马替尼治疗。该治疗未显示出副作用，随后的结肠镜检查未见异常。
在最初出现模糊腹痛后12个月才确诊，这凸显了提高临床怀疑度的必要性，以便在切除可能治愈的早期阶段检测出GISTs。特别是结肠GIST，可能会出现类似卵巢囊肿的表现，如本病例所示。本病例报告证实，高级别GIST患者可以通过伊马替尼治疗得到有效治疗。然而，治疗持续时间可能因肿瘤分级和副作用而有所不同。
