School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring Road, Chaoyang District, Beijing 100029, China.
Acupuncture and Moxibustion Department, The Third Hospital of Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Evid Based Complement Alternat Med. 2014;2014:691863. doi: 10.1155/2014/691863. Epub 2014 Mar 20.
The aim of the present paper was to observe the effects of needling ST40 and PC6 on IL-17 of ApoE(-/-) mice with fatty liver. Forty male ApoE(-/-) mice were randomized into Needling-Acupoint Group, Simvastatin Intragastric Administration Group, Needling Nonacupoint Group, and Model Group. Each was fed with high fat diet for 8 weeks since 16 weeks of age; after 8 weeks of intervention, mice were sacrificed and tested for various examinations. Result showed that the body weight, TC, and serum IL-17 in Needling-Acupoint Group decreased. Compared with Model Group, the immunohistochemical expressions of IL-17 in liver tissue were significantly decreased among the other three groups. In conclusion, acupuncture was able to lower the expression of IL-17 level both in serum and liver tissue in ApoE(-/-) mice, which is helpful to reduce the inflammation and defers the progress from fatty liver to cirrhosis.
本研究旨在观察针刺 ST40 和 PC6 对载脂蛋白 E 基因敲除（ApoE(-/-)）小鼠脂肪肝模型白细胞介素 17（IL-17）的影响。40 只雄性 ApoE(-/-)小鼠随机分为针刺穴位组、辛伐他汀灌胃组、针刺非穴位组和模型组。16 周龄起，每组给予高脂饲料喂养 8 周；干预 8 周后处死小鼠并进行各项检测。结果显示，针刺穴位组的体重、总胆固醇（TC）和血清白细胞介素 17（IL-17）水平降低。与模型组相比，其他三组肝组织中 IL-17 的免疫组化表达均显著降低。综上所述，针刺可降低 ApoE(-/-) 小鼠血清和肝组织中 IL-17 水平，有助于减轻炎症反应，延缓从脂肪肝向肝硬化的进展。
