Murray C M, Stone G M
Department of Veterinary Physiology, University of Sydney, N.S.W., Australia.
Reprod Fertil Dev. 1989;1(2):107-15. doi: 10.1071/rd9890107.
The delayed response of the uterus of the ovariectomized mouse to progesterone (P) required the presence of a low dose of oestradiol-17 beta (E2) and was associated with a maintained level of uterine DNA, an increase in RNA:DNA ratio and in total tissue protein and a decreased level of uterine P. This last parameter was associated with an increased level of in vitro metabolism of P by the uterus. Changes in the level of receptors for P and E2 were temporally unrelated to the delayed response. Omission of oestradiol every second, third or fourth day inhibited development of the delayed response, which could also be obtained with the long acting progestogen, medroxy progesterone acetate, and E2 or oestradiol benzoate.
卵巢切除小鼠子宫对孕酮（P）的延迟反应需要低剂量的17β-雌二醇（E2）存在，并且与子宫DNA水平维持、RNA:DNA比值增加、总组织蛋白增加以及子宫P水平降低有关。最后一个参数与子宫对P的体外代谢水平增加有关。P和E2受体水平的变化在时间上与延迟反应无关。每隔一天、两天或四天省略雌二醇会抑制延迟反应的发展，使用长效孕激素醋酸甲羟孕酮以及E2或苯甲酸雌二醇也可获得延迟反应。
