中国人群中TLR4基因多态性与糖尿病肾病之间无关联。
Lack of association between TLR4 genetic polymorphisms and diabetic nephropathy in a Chinese population.
作者信息
Peng Danfeng, Wang Jie, Pan Jiemin, Zhang Rong, Tang Shanshan, Jiang Feng, Chen Miao, Yan Jing, Sun Xue, Wang Tao, Wang Shiyun, Bao Yuqian, Jia Weiping
机构信息
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
出版信息
Biomed Res Int. 2014;2014:704167. doi: 10.1155/2014/704167. Epub 2014 Mar 23.
OBJECTIVE
Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population.
METHODS
Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy.
RESULTS
None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either.
CONCLUSION
We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.
目的
Toll样受体4（TLR4）在先天免疫中起核心作用。先天免疫反应的激活及随后的慢性低度炎症被认为参与了糖尿病肾病的发病机制。在本研究中，我们旨在调查TLR4基因变异是否与中国人群的糖尿病肾病相关。
方法
基于HapMap中国数据，对1455例中国2型糖尿病患者的TLR4的7个标签单核苷酸多态性（SNP）进行基因分型。这些患者中，622例被诊断为糖尿病肾病，833例为糖尿病病程超过5年但无糖尿病肾病的患者。
结果
在我们的研究中，没有SNP和单倍型显示出与糖尿病肾病有显著关联。也未观察到SNP与定量性状之间的关联。
结论
我们得出结论，TLR4基因内的常见变异与中国2型糖尿病患者的糖尿病肾病无关。
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