AMP 激活的蛋白激酶亚单位α 2（PRKAA2）基因多态性对中国人群 2 型糖尿病及糖尿病肾病易感性的影响。
Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population.
机构信息
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Department of Key Laboratory of Endocrinology, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China.
出版信息
J Diabetes. 2018 Jan;10(1):43-49. doi: 10.1111/1753-0407.12553. Epub 2017 Jul 13.
BACKGROUND
It is well known that AMP-activated protein kinase (AMPK) is a key factor affecting the development of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism (SNP) rs2746342 in the AMPK alpha 2 subunit gene (PRKAA2) has been found to be associated with susceptibility to T2DM in the Chinese Han population. The present study further investigates the association of PRKAA2 genotypes with susceptibility to T2DM and its complication, diabetic nephropathy.
METHODS
The PRKAA2 genotypes of 406 T2DM patients and 214 controls from the Chinese Han population were determined with regard to SNPs rs10789038, rs2796498 and rs2746342. The association between these SNPs and susceptibility to T2DM and diabetic nephropathy was evaluated. The clinical characteristics differed significantly between T2DM patients and controls.
RESULTS
After adjustment for age, sex and body mass index, there was an obvious relationship between T2DM and both rs10789038 (odds ratio [OR] 1.634; P = 0.015) and rs2796498 (OR 0.656; P = 0.030), but not rs2746342. There was haplotype association of PRKAA2 rs10789038-rs2796498-rs2746342 with T2DM susceptibility. In addition, rs2796498 was found to be related to the susceptibility to diabetic nephropathy.
CONCLUSIONS
Polymorphisms in rs10789038 and rs2796498 are associated with the susceptibility to T2DM, and rs2796498 may be related to diabetic nephropathy.
背景
众所周知，腺苷酸活化蛋白激酶（AMPK）是影响 2 型糖尿病（T2DM）发展的关键因素。AMPKα2 亚基基因（PRKAA2）中的单核苷酸多态性（SNP）rs2746342 已被发现与中国汉族人群 T2DM 的易感性相关。本研究进一步探讨了 PRKAA2 基因型与 T2DM 及其并发症糖尿病肾病易感性的关系。
方法
本研究采用 SNP rs10789038、rs2796498 和 rs2746342 对来自中国汉族人群的 406 例 T2DM 患者和 214 例对照者的 PRKAA2 基因型进行了检测。评估了这些 SNP 与 T2DM 和糖尿病肾病易感性的关系。T2DM 患者和对照组的临床特征存在显著差异。
结果
在调整年龄、性别和体重指数后，T2DM 与 rs10789038（比值比 [OR] 1.634；P = 0.015）和 rs2796498（OR 0.656；P = 0.030）明显相关，但与 rs2746342 无关。PRKAA2 rs10789038-rs2796498-rs2746342 单体型与 T2DM 易感性相关。此外，rs2796498 与糖尿病肾病的易感性相关。
结论
rs10789038 和 rs2796498 多态性与 T2DM 的易感性相关，rs2796498 可能与糖尿病肾病有关。
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