van den Brandt Piet A, Brandts Lloyd
Department of Epidemiology, Maastricht University Medical Centre, GROW- School for Oncology and Developmental Biology, Maastricht, The Netherlands.
Department of Epidemiology, Maastricht University Medical Centre, Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.
Age Ageing. 2020 Apr 27;49(3):395-402. doi: 10.1093/ageing/afaa003.
whether light-to-moderate alcohol intake is related to reduced mortality remains a subject of intense research and controversy. There are very few studies available on alcohol and reaching longevity.
we investigated the relationship of alcohol drinking characteristics with the probability to reach 90 years of age. Analyses were conducted using data from the Netherlands Cohort Study. Participants born in 1916-1917 (n = 7,807) completed a questionnaire in 1986 (age 68-70 years) and were followed up for vital status until the age of 90 years (2006-07). Multivariable Cox regression analyses with fixed follow-up time were based on 5,479 participants with complete data to calculate risk ratios (RRs) of reaching longevity (age 90 years).
we found statistically significant positive associations between baseline alcohol intake and the probability of reaching 90 years in both men and women. Overall, the highest probability of reaching 90 was found in those consuming 5- < 15 g/d alcohol, with RR = 1.36 (95% CI, 1.20-1.55) when compared with abstainers. The exposure-response relationship was significantly non-linear in women, but not in men. Wine intake was positively associated with longevity (notably in women), whereas liquor was positively associated with longevity in men and inversely in women. Binge drinking pointed towards an inverse relationship with longevity. Alcohol intake was associated with longevity in those without and with a history of selected diseases.
the highest probability of reaching 90 years was found for those drinking 5- < 15 g alcohol/day. Although not significant, the risk estimates also indicate to avoid binge drinking.
轻度至中度饮酒是否与死亡率降低相关仍是深入研究和争论的主题。关于酒精与长寿的研究非常少。
我们调查了饮酒特征与活到90岁概率之间的关系。使用荷兰队列研究的数据进行分析。1916年至1917年出生的参与者（n = 7807）于1986年（68 - 70岁）完成了一份问卷，并随访其生命状态直至90岁（2006 - 2007年）。基于5479名有完整数据的参与者进行固定随访时间的多变量Cox回归分析，以计算活到90岁（长寿）的风险比（RRs）。
我们发现男性和女性的基线饮酒量与活到90岁的概率之间存在统计学上显著的正相关。总体而言，饮酒量为5 - ＜15克/天的人群活到90岁的概率最高，与不饮酒者相比，RR = 1.36（95%CI，1.20 - 1.55）。女性的暴露 - 反应关系显著呈非线性，而男性则不然。葡萄酒摄入量与长寿呈正相关（特别是在女性中），而白酒摄入量在男性中与长寿呈正相关，在女性中呈负相关。暴饮与长寿呈负相关。无论有无特定疾病史，饮酒都与长寿相关。
每天饮酒5 - ＜15克的人群活到90岁的概率最高。虽然不显著，但风险估计也表明应避免暴饮。
