Reed D M, Foley D J, White L R, Heimovitz H, Burchfiel C M, Masaki K
Buck Center for Research in Aging, Novato, Calif., USA.
Am J Public Health. 1998 Oct;88(10):1463-8. doi: 10.2105/ajph.88.10.1463.
The purpose of this study was to identify risk factors that consistently predict staying healthy in contrast to developing clinical illness and/or physical and mental impairments.
More than 8000 men of Japanese ancestry were followed for 28 years with repeat examinations and surveillance for deaths and incident clinical illness. Physical and cognitive functions were measured in 1993. Measures of healthy aging included surviving and remaining free of major chronic illnesses and physical and cognitive impairments.
Of 6505 healthy men at baseline, 2524 (39%) died prior to the final exam. Of the 3263 available survivors, 41% remained free of major clinical illnesses, 40% remained free of both physical and cognitive impairment, and 19% remained free of both illness and impairment. The most consistent predictors of healthy aging were low blood pressure, low serum glucose, not smoking cigarettes, and not being obese.
Beyond the biological effects of aging, much of the illness and disability in the elderly is related to risk factors present at midlife.
本研究的目的是确定与罹患临床疾病和/或身心损伤相比，能够持续预测保持健康的风险因素。
对8000多名日本裔男性进行了28年的随访，进行重复检查，并监测死亡情况和新发临床疾病。1993年对身体和认知功能进行了测量。健康老龄化的指标包括存活且未患重大慢性疾病以及未出现身体和认知损伤。
在基线时的6505名健康男性中，2524人（39%）在期末考试前死亡。在3263名存活者中，41%未患重大临床疾病，40%未出现身体和认知损伤，19%既未患病也未出现损伤。健康老龄化最一致的预测因素是低血压、低血糖、不吸烟和不肥胖。
除了衰老的生物学影响外，老年人的许多疾病和残疾与中年时存在的风险因素有关。
