猕猴月经周期中对猿猴免疫缺陷病毒的易感性变化。
SHIV susceptibility changes during the menstrual cycle of pigtail macaques.
作者信息
Kersh Ellen N, Henning Tara, Vishwanathan Sundaram A, Morris Monica, Butler Katherine, Adams Debra R, Guenthner Patricia, Srinivasan Priya, Smith James, Radzio Jessica, Garcia-Lerma J Gerardo, Dobard Charles, Heneine Walid, McNicholl Janet
机构信息
Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
J Med Primatol. 2014 Oct;43(5):310-6. doi: 10.1111/jmp.12124. Epub 2014 Apr 29.
Abstract
BACKGROUND
Hormonal changes during menstrual cycling may affect susceptibility to HIV.
METHODS
We determined the simian human immunodeficiency virus (SHIV) acquisition time point in 43 cycling pigtail macaques infected by repeated vaginal virus exposures initiated randomly in the cycle.
RESULTS
SHIV infection was first detected in the follicular phase in 38 macaques (88%), and in the luteal phase in five macaques (12%), indicating a statistically significant timing difference. Assuming a 7-day eclipse phase, most infections occurred during or following a high-progesterone period associated with menstruation, vaginal epithelium thinning, and suppressed mucosal immunity.
CONCLUSIONS
This raises questions whether other high-progesterone conditions (pregnancy, hormonal contraception) similarly affect HIV risk.
摘要
背景
月经周期中的激素变化可能会影响对艾滋病毒的易感性。
方法
我们确定了43只处于月经周期的猪尾猕猴在通过在月经周期中随机开始的反复阴道病毒暴露感染猿猴人类免疫缺陷病毒（SHIV）的时间点。
结果
在38只猕猴（88%）的卵泡期首次检测到SHIV感染，在5只猕猴（12%）的黄体期检测到感染，表明在时间上存在统计学显著差异。假设潜伏期为7天，大多数感染发生在与月经、阴道上皮变薄和黏膜免疫抑制相关的高孕酮期或之后。
结论
这引发了其他高孕酮状态（怀孕、激素避孕）是否同样影响艾滋病毒感染风险的问题。
相似文献
1
SHIV susceptibility changes during the menstrual cycle of pigtail macaques.
J Med Primatol. 2014 Oct;43(5):310-6. doi: 10.1111/jmp.12124. Epub 2014 Apr 29.
2
Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques.
Sex Transm Dis. 2015 Dec;42(12):694-701. doi: 10.1097/OLQ.0000000000000367.
3
High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques.
J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):261-4. doi: 10.1097/QAI.0b013e318220ebd3.
4
Analysis of putative mucosal SHIV susceptibility factors during repeated DMPA treatments in pigtail macaques.
J Med Primatol. 2015 Oct;44(5):286-95. doi: 10.1111/jmp.12188. Epub 2015 Aug 4.
5
Short Communication: Practical Experience with Analysis and Design of Repeat Low-Dose SHIVSF162P3 Exposure Studies in Female Pigtail Macaques with Varying Susceptibility During Menstrual Cycling.
AIDS Res Hum Retroviruses. 2015 Nov;31(11):1166-9. doi: 10.1089/AID.2014.0373. Epub 2015 Aug 6.
6
Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle.
Am J Reprod Immunol. 2014 Apr;71(4):322-9. doi: 10.1111/aji.12201. Epub 2014 Feb 13.
7
A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model.
J Med Primatol. 2015 Apr;44(2):97-107. doi: 10.1111/jmp.12157. Epub 2014 Dec 23.
8
Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251.
J Med Primatol. 2015 Oct;44(5):301-5. doi: 10.1111/jmp.12177. Epub 2015 Jun 5.
9
Evaluation of pigtail macaques as a model for the effects of copper intrauterine devices on HIV infection.
J Med Primatol. 2014 Oct;43(5):349-59. doi: 10.1111/jmp.12096. Epub 2013 Dec 27.
10
Proinflammatory oscillations over the menstrual cycle drives bystander CD4 T cell recruitment and SHIV susceptibility from vaginal challenge.
EBioMedicine. 2021 Jul;69:103472. doi: 10.1016/j.ebiom.2021.103472. Epub 2021 Jul 3.
引用本文的文献
1
Do endometrial immune changes with age prior to menopause compromise fertility in women?
Explor Immunol. 2022;2(5):677-692. doi: 10.37349/ei.2022.00076. Epub 2022 Oct 29.
2
Minimally Modified HIV-1 Infection of Macaques: Development, Utility, and Limitations of Current Models.
Viruses. 2024 Oct 16;16(10):1618. doi: 10.3390/v16101618.
3
Differential expression of HIV target cells CCR5 and α4β7 in tissue resident memory CD4 T cells in endocervix during the menstrual cycle of HIV seronegative women.
Front Immunol. 2024 Sep 25;15:1456652. doi: 10.3389/fimmu.2024.1456652. eCollection 2024.
4
Defining blood hematology reference values in female pig-tailed macaques (Macaca nemestrina) using the Isolation Forest algorithm.
J Med Primatol. 2024 Aug;53(4):e12723. doi: 10.1111/jmp.12723.
5
Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD.
Clin Immunol. 2023 Oct;255:109750. doi: 10.1016/j.clim.2023.109750. Epub 2023 Sep 3.
6
Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial.
Front Reprod Health. 2022 Mar 3;4:781687. doi: 10.3389/frph.2022.781687. eCollection 2022.
7
Increased HIV-1 infection in PBMCs treated in vitro with menstrual cycle phase hormones or medroxyprogesterone acetate likely occurs via different mechanisms.
Am J Reprod Immunol. 2022 Dec;88(6):e13643. doi: 10.1111/aji.13643. Epub 2022 Nov 2.
8
Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data.
BMC Med. 2022 Oct 5;20(1):353. doi: 10.1186/s12916-022-02532-9.
9
Sex Hormones and Aging Modulate Interferon Lambda 1 Production and Signaling by Human Uterine Epithelial Cells and Fibroblasts.
Front Immunol. 2021 Sep 24;12:718380. doi: 10.3389/fimmu.2021.718380. eCollection 2021.
10
Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques.
AIDS Res Hum Retroviruses. 2021 Jul;37(7):510-522. doi: 10.1089/AID.2020.0271. Epub 2021 Jun 22.
本文引用的文献
1
Increased susceptibility to vaginal simian/human immunodeficiency virus transmission in pig-tailed macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis.
J Infect Dis. 2014 Oct 15;210(8):1239-47. doi: 10.1093/infdis/jiu240. Epub 2014 Apr 21.
2
Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16145-50. doi: 10.1073/pnas.1311355110. Epub 2013 Sep 16.
3
Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract.
J Virol. 2013 Nov;87(21):11388-400. doi: 10.1128/JVI.01377-13. Epub 2013 Aug 21.
4
Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence.
Lancet Infect Dis. 2013 Sep;13(9):797-808. doi: 10.1016/S1473-3099(13)70155-5. Epub 2013 Jul 19.
5
Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen.
PLoS One. 2012;7(12):e50632. doi: 10.1371/journal.pone.0050632. Epub 2012 Dec 4.
6
High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques.
J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):261-4. doi: 10.1097/QAI.0b013e318220ebd3.
7
Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
J Virol. 2010 Oct;84(19):10406-12. doi: 10.1128/JVI.01155-10. Epub 2010 Aug 4.
8
Does intercourse during menses increase the risk for sexually transmitted disease?
Arch Gynecol Obstet. 2010 Dec;282(6):627-30. doi: 10.1007/s00404-010-1564-4. Epub 2010 Jun 25.
9
Resistance to Simian HIV infection is associated with high plasma interleukin-8, RANTES and Eotaxin in a macaque model of repeated virus challenges.
J Acquir Immune Defic Syndr. 2010 Apr;53(5):574-81. doi: 10.1097/QAI.0b013e3181d3521f.
10
A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle.
AIDS. 2008 Oct 1;22(15):1909-17. doi: 10.1097/QAD.0b013e3283060ea4.
Zotero 插件