a Department of Pharmacology , All India Institute of Medical Sciences , New Delhi, 110029 , India.
Food Addit Contam Part B Surveill. 2012;5(2):140-4. doi: 10.1080/19393210.2012.680612. Epub 2012 May 9.
The quality and safety of Ayurvedic formulations has become a serious issue, as this Indian system of medicine is used by 80% of the Indian population. Hence, the present study was performed to evaluate heavy metals contents by flame atomic absorbance spectroscopy (AAS) measurements and confirmation by inductive coupled plasma-mass spectroscopy (ICP-MS). A total of 78 formulations (56 herbal, 19 herbometallic and 3 metallic) were sampled. In herbal formulations, lead in 19.6% (11/56), cadmium in 21.4% (12/56), mercury and arsenic in 5.3% (3/56) were above the limit. Lead in 52.6% (10/19) of samples, cadmium in 26.3% (5/19) and mercury and arsenic contained in one herbometallic sample was above the limit. Heavy metals in all metal formulations were above the WHO limit. Significant batch variation was observed. The analytical results of flame AAS and ICP-MS did not differ significantly in the range of measurements in this study, which proves that both methods are satisfactory for estimation of heavy metals in these type of samples.
阿育吠陀制剂的质量和安全性已成为一个严重的问题，因为这种印度医学体系被 80%的印度人口使用。因此，本研究旨在通过火焰原子吸收光谱法（AAS）测量和电感耦合等离子体质谱法（ICP-MS）来评估重金属含量。共采集了 78 种制剂（56 种草药、19 种草药-金属和 3 种金属）。在草药制剂中，19.6%（11/56）的制剂中含有铅，21.4%（12/56）的制剂中含有镉，5.3%（3/56）的制剂中含有汞和砷超过了限量。52.6%（10/19）的草药-金属制剂中含有铅，26.3%（5/19）的制剂中含有镉，1 种草药-金属制剂中含有汞和砷超过了限量。所有金属制剂中的重金属均超过了世界卫生组织的限量。观察到显著的批次差异。在本研究的测量范围内，火焰 AAS 和 ICP-MS 的分析结果没有显著差异，这证明这两种方法都可以满足对这类样品中重金属的估计。
