Desloovere C, Lörz M, Klima A
Department of Otorhinolaryngology, University of Frankfurt, West-Germany.
Acta Otorhinolaryngol Belg. 1989;43(1):31-7.
The effect of a hemodilution therapy for sudden sensorineural hearing loss was analysed comparing the results of a prospective randomised double blind study and a retrospective study at the Frankfurt university. The prospective study consists of a treatment group receiving infusions with hydroxyethyl starch-pentoxifyllin and a control group with infusions with normal saline. Another patient group receiving hydroxyethyl starch-pentoxifyllin-naftidrofuryl infusions was analysed retrospectively. The overall therapy results are in the same range for all 3 groups. However patients with a hemoglobin value above 14 mg % in the control group had a poorer result compared to the other groups. The patient group with systolic blood pressure above 130 mm Hg treated with hydroxyethyl starch-pentoxifyllin had a significant hearing improvement over normal saline and hydroxyethyl starch-pentoxifyllin-naftidrofuryl. With increasing systolic blood pressure, patients in the control and hydroxyethyl starch-pentoxifyllin-naftidrofuryl groups had a statistically significant lower therapy result.
通过比较法兰克福大学一项前瞻性随机双盲研究和一项回顾性研究的结果，分析了血液稀释疗法对突发性感音神经性听力损失的疗效。前瞻性研究包括一个接受羟乙基淀粉 - 己酮可可碱输注的治疗组和一个接受生理盐水输注的对照组。对另一个接受羟乙基淀粉 - 己酮可可碱 - 萘呋胺酯输注的患者组进行了回顾性分析。所有3组的总体治疗结果处于相同范围。然而，对照组中血红蛋白值高于14mg%的患者与其他组相比结果较差。接受羟乙基淀粉 - 己酮可可碱治疗的收缩压高于130mmHg的患者组与生理盐水组和羟乙基淀粉 - 己酮可可碱 - 萘呋胺酯组相比，听力有显著改善。随着收缩压升高，对照组和羟乙基淀粉 - 己酮可可碱 - 萘呋胺酯组的患者治疗结果在统计学上显著降低。
