Johansson O, Sandberg G
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Acta Physiol Scand. 1989 Sep;137(1):107-11. doi: 10.1111/j.1748-1716.1989.tb08726.x.
Various neuropeptides were tested in a wide dose range for an effect on lymphocyte-proliferation. The response of spleen cells to the mitogen phytohaemagglutinin (PHA) was stimulated by somatostatin in doses ranging from 10(-6) to 10(-18) M. The effect of somatostatin was only seen when the peptide was added at the start of incubation, indicating an effect on the inductive phase of mitogen stimulation. Weak stimulative effects were also seen of somatostatin (10(-6) M) on spontaneous proliferation of thymocytes and of beta-MSH on PHA-treated thymocytes and PHA-treated spleen cells when the peptide was added after 24 h of culture.
对多种神经肽在很宽的剂量范围内进行了测试，以观察其对淋巴细胞增殖的影响。生长抑素在10⁻⁶至10⁻¹⁸M的剂量范围内可刺激脾细胞对丝裂原植物血凝素（PHA）的反应。生长抑素的作用仅在孵育开始时添加该肽时才可见，表明其对丝裂原刺激的诱导期有影响。当在培养24小时后添加该肽时，生长抑素（10⁻⁶M）对胸腺细胞的自发增殖以及β-促黑激素对PHA处理的胸腺细胞和PHA处理的脾细胞也有微弱的刺激作用。
