Widenfalk B, Wiberg M
Department of Plastic Surgery, Uppsala University Hospital, Sweden.
Anat Embryol (Berl). 1989;180(4):317-23. doi: 10.1007/BF00311164.
The origin of sympathetic and sensory innervation of the knee joint was investigated by the intra-axonal transport method. After injection of horseradish peroxidase (HRP) or horseradish peroxidase conjugated to wheat germ agglutinin (WGA-HRP) into the knee joint unilaterally in adult rats, labelled neurons were found ipsilaterally both in sympathetic and dorsal root ganglia at the lower thoracic and lumbosacral levels. A maximum of 1500 and 1000 peroxidase-positive cells were observed in the sympathetic and dorsal root ganglia, respectively; in the former they were mainly located at the levels of L2-L4, and in the latter mainly at L3-L5. The functional implications of the above observations are discussed in relation to pain mechanisms in joints and to the earlier hypothesis that a nervous component might be involved in the pathogenesis of chronic joint inflammation.
采用轴突内运输法研究了膝关节交感神经和感觉神经支配的起源。在成年大鼠单侧膝关节内注射辣根过氧化物酶（HRP）或与麦胚凝集素结合的辣根过氧化物酶（WGA-HRP）后，在胸下部和腰骶部水平的交感神经节和背根神经节同侧发现了标记神经元。在交感神经节和背根神经节中分别观察到最多1500个和1000个过氧化物酶阳性细胞；在前者中，它们主要位于L2-L4水平，在后者中主要位于L3-L5水平。结合关节疼痛机制以及早期关于神经成分可能参与慢性关节炎症发病机制的假说，讨论了上述观察结果的功能意义。
