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[一例对大剂量化疗联合自体骨髓移植呈现完全缓解的难治性睾丸癌病例]

[A case of refractory testicular cancer showing complete response to high-dose chemotherapy with autologous bone marrow transplantation].

作者信息

Ishii H, Osa Y, Okano T, Isaka S, Yasuda K, Shimazaki J, Komori I, Kodo H, Asano S

机构信息

Dept. of Urology, School of Medicine, Chiba University.

出版信息

Gan To Kagaku Ryoho. 1989 Oct;16(10):3483-6.

PMID:2478078
Abstract

A patient with stage III testicular cancer was treated by 3 courses of BEP therapy and a partial response was obtained. Afterwards he underwent resection of pulmonary residual tumors and was treated by 2 courses of PE therapy immediately after operation. However, a new pulmonary tumor appeared after the first course of PE therapy was completed. He was treated by high-dose chemotherapy (etoposide 1200 mg/m2, cyclophosphamide 120 mg/kg, CDDP 60 mg/m2) with autologous bone marrow transplantation. Three weeks after high-dose chemotherapy his metastatic pulmonary tumor showed cavity formation which disappeared after 3 months. Fifteen months after the high-dose chemotherapy, no evidence of disease has been seen even without maintenance therapy.

摘要

一名III期睾丸癌患者接受了3个疗程的BEP治疗,获得了部分缓解。之后他接受了肺部残留肿瘤切除术,并在术后立即接受了2个疗程的PE治疗。然而,在完成第一个疗程的PE治疗后出现了新的肺部肿瘤。他接受了高剂量化疗(依托泊苷1200 mg/m²、环磷酰胺120 mg/kg、顺铂60 mg/m²)并进行了自体骨髓移植。高剂量化疗3周后,他的转移性肺部肿瘤出现空洞形成,3个月后空洞消失。高剂量化疗15个月后,即使没有维持治疗也未发现疾病迹象。

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