Schaefer Alexander, Quinque Eva M, Kipping Judy A, Arélin Katrin, Roggenhofer Elisabeth, Frisch Stefan, Villringer Arno, Mueller Karsten, Schroeter Matthias L
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
1] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany [2] Leipzig Research Center for Civilization Diseases, University Leipzig, Leipzig, Germany [3] Clinic of Cognitive Neurology, University Leipzig, Leipzig, Leipzig, Germany.
J Cereb Blood Flow Metab. 2014 Jul;34(7):1091-5. doi: 10.1038/jcbfm.2014.70. Epub 2014 Apr 30.
Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.
脑小血管病主要以白质病变和腔隙为特征，因其会导致血管性痴呆，所以具有很高的临床影响。最近的研究表明，这种疾病会损害额顶叶网络。在此，我们应用静息态磁共振成像和数据驱动的全脑成像分析方法（特征向量中心性）来研究早期小血管病中功能连接组的变化。我们发现额顶叶网络的连接性降低，而小脑的连接性增加。这些功能变化与白质病变以及与小血管病相关的典型神经心理学缺陷密切相关。
