Stevens Robert D, Hannawi Yousef, Sair Haris
1] Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [3] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [4] Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
1] Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Cereb Blood Flow Metab. 2014 Jul;34(7):1089-90. doi: 10.1038/jcbfm.2014.69. Epub 2014 Apr 30.
Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.
小血管疾病（SVD）与认知障碍和痴呆症有关，但对于SVD患者的功能激活情况却知之甚少。静息态功能磁共振成像记录表明，前额叶、顶叶和扣带回节点的连接性降低，而小脑的连接性则相应增加，这些改变可预测神经心理学测试表现。结合扩散张量成像研究，这些数据支持了一种连接性中断模型，该模型是一种从系统层面探讨SVD中所见认知障碍的方法。
