Mel'nikova A V, Shugaĭlov I A, Garus Ia N
Stomatologiia (Mosk). 2014;93(2):43-6.
The study evaluated duration and depth of the local infiltration anesthesia by articaine with different combinations of epinephrine and clonidine : articaine (4%) + epinephrine (1: 200 000), articaine (4%) + clonidine (1:100 000), articaine (4%) + epinephrine (1:200 000) + clonidine (1:100 000), articaine (4%) + epinephrine (1: 400 000) + clonidine (1:100, 000) in pediatric dental practice. It was revealed that the replacement of the vasoconstrictor epinephrine on clonidine associated with reduced depth and duration of analgesia. This increased efficiency is provided by inclusion of epinephrine (1:200 000), and clonidine (1:100 000) into anesthetic solution, which provided statistically significant increase in depth and duration of anesthesia.
该研究评估了在儿童牙科治疗中，阿替卡因与不同组合的肾上腺素和可乐定联合使用时局部浸润麻醉的持续时间和深度：阿替卡因（4%）+肾上腺素（1:200 000）、阿替卡因（4%）+可乐定（1:100 000）、阿替卡因（4%）+肾上腺素（1:200 000）+可乐定（1:100 000）、阿替卡因（4%）+肾上腺素（1:400 000）+可乐定（1:100 000）。结果显示，用可乐定替代血管收缩剂肾上腺素会导致镇痛深度和持续时间降低。将肾上腺素（1:200 000）和可乐定（1:100 000）加入麻醉溶液可提高效率，这在统计学上显著增加了麻醉的深度和持续时间。
