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基于促性腺激素释放激素拮抗剂的体外受精方案。

GnRH antagonist-based protocols for in vitro fertilization.

作者信息

Reichman David, Rosenwaks Zev

机构信息

Center of Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY, USA,

出版信息

Methods Mol Biol. 2014;1154:289-304. doi: 10.1007/978-1-4939-0659-8_13.

DOI:10.1007/978-1-4939-0659-8_13
PMID:24782015
Abstract

In this chapter we elaborate on the intricacies of employing GnRH antagonists for prevention of the endogenous luteinizing hormone surge during IVF. Several practical aspects of implementing a GnRH antagonist-based stimulation protocol are described; selection of the correct dose, choosing when to start the antagonist, programming of cycle starts, selection of the appropriate gonadotropins, and triggering of final oocyte maturation are elucidated.

摘要

在本章中,我们详细阐述了在体外受精过程中使用促性腺激素释放激素(GnRH)拮抗剂来预防内源性促黄体生成素激增的复杂性。描述了实施基于GnRH拮抗剂的刺激方案的几个实际方面;阐明了正确剂量的选择、开始使用拮抗剂的时间、周期开始的安排、合适促性腺激素的选择以及最终卵母细胞成熟的触发。

相似文献

1
GnRH antagonist-based protocols for in vitro fertilization.基于促性腺激素释放激素拮抗剂的体外受精方案。
Methods Mol Biol. 2014;1154:289-304. doi: 10.1007/978-1-4939-0659-8_13.
2
[Biological assessment criteria during antagonist protocols].[拮抗剂方案中的生物学评估标准]
J Gynecol Obstet Biol Reprod (Paris). 2004 Oct;33(6 Pt 2):3S32-5.
3
Combined administration of gonadotropin-releasing hormone agonist with human chorionic gonadotropin for final oocyte maturation in GnRH antagonist cycles for in vitro fertilization.在体外受精的GnRH拮抗剂周期中,联合使用促性腺激素释放激素激动剂与人绒毛膜促性腺激素进行最终卵母细胞成熟。
J Reprod Med. 2014 Jan-Feb;59(1-2):63-8.
4
A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists.在接受 GnRH 拮抗剂方案体外受精的患者中,当使用 GnRH 激动剂而非 HCG 来触发最终卵母细胞成熟时,预期持续妊娠率会更低。
Hum Reprod. 2005 Oct;20(10):2887-92. doi: 10.1093/humrep/dei150. Epub 2005 Jun 24.
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[Comparison of the efficiency between in-vitro maturation and in-vitro fertilization after early follicular phase GnRH agonist down-regulation in infertile women with polycystic ovary syndrome].多囊卵巢综合征不孕女性卵泡早期GnRH激动剂降调节后体外成熟与体外受精效率的比较
Zhonghua Fu Chan Ke Za Zhi. 2013 Nov;48(11):833-7.
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GnRH antagonists in ovarian stimulation for IVF.用于体外受精卵巢刺激的促性腺激素释放激素拮抗剂
Hum Reprod Update. 2006 Jul-Aug;12(4):333-40. doi: 10.1093/humupd/dml001. Epub 2006 Mar 27.
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Early luteal phase endocrine profile is affected by the mode of triggering final oocyte maturation and the luteal phase support used in recombinant follicle-stimulating hormone-gonadotropin-releasing hormone antagonist in vitro fertilization cycles.早黄体期内分泌谱受触发卵母细胞最终成熟的方式和黄体期支持治疗的影响,这些治疗方法在重组卵泡刺激素-促性腺激素释放激素拮抗剂体外受精周期中使用。
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Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a "freeze-all" strategy: a prospective multicentric study.促性腺激素释放激素激动剂触发拮抗剂方案中最后一个卵母细胞成熟以预防卵巢过度刺激综合征:一项结合“冻存所有”策略的前瞻性多中心研究。
Fertil Steril. 2011 May;95(6):2029-33, 2033.e1. doi: 10.1016/j.fertnstert.2011.01.163. Epub 2011 Mar 2.
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GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol.超短激动方案联合 GnRH 拮抗剂方案中 GnRH 激动剂扳机对控制性卵巢刺激超排卵行 IVF 患者的作用。
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[Clinical application of gonadotropin-releasing hormone antagonist in Chinese women undergoing controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer].促性腺激素释放激素拮抗剂在中国接受体外受精-胚胎移植控制性卵巢刺激的女性中的临床应用
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Natural frozen embryo transfer with hCG booster leads to improved cycle outcomes: a retrospective cohort study.自然冻融胚胎移植加用 hCG 扳机可改善周期结局:一项回顾性队列研究。
J Assist Reprod Genet. 2020 May;37(5):1177-1182. doi: 10.1007/s10815-020-01740-7. Epub 2020 Mar 20.
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One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date.1078 个 45 岁及以上女性的自体 IVF 周期:目前为止最大的单一中心队列。
J Assist Reprod Genet. 2018 Mar;35(3):435-440. doi: 10.1007/s10815-017-1088-y. Epub 2017 Nov 16.
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Replacing single frozen-thawed euploid embryos in a natural cycle in ovulatory women may increase live birth rates compared to medicated cycles in anovulatory women.
在排卵正常的女性自然周期中,替换单个冻融的整倍体胚胎可能会比在排卵障碍的女性中进行药物周期治疗增加活产率。
J Assist Reprod Genet. 2017 Oct;34(10):1325-1331. doi: 10.1007/s10815-017-0983-6. Epub 2017 Jun 24.
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Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 IVF-ICSI cycles.滑动剂量人绒毛膜促性腺激素扳机法产生等效的妊娠结局并降低卵巢过度刺激综合征:对10427个体外受精-卵胞浆内单精子注射周期的分析。
PLoS One. 2017 Apr 25;12(4):e0176019. doi: 10.1371/journal.pone.0176019. eCollection 2017.