The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, 1305 York Ave, New York, NY, 10021, USA.
J Assist Reprod Genet. 2020 May;37(5):1177-1182. doi: 10.1007/s10815-020-01740-7. Epub 2020 Mar 20.
To determine whether luteal support with intramuscular injection of human chorionic gonadotropin 1 day post-LH surge in natural cycle frozen embryo transfer (nFETs) increases ongoing pregnancy rates (OPR).
Retrospective cohort study of women who underwent natural cycle FET with transfer of a single day-5 or - 6 euploid blastocyst between January 2017 and December 2018 at an academic medical center were divided into two groups based on whether they received hCG 1 day post-LH surge. Patients with uterine factor infertility were excluded.
A total of 529 nFET cycles were included. The OPR was significantly higher in the treatment group than in the non-treatment group when controlling for potential confounders such as embryo morphology (69.9% versus 57.4%, p = 0.0119, aOR1.724, 95% CI 1.13-2.65). There were no significant differences observed in the rates of first trimester loss (aOR 1.05, 95% CI 0.032-2.96) or biochemical pregnancy (aOR 0.79, 95% CI 0.31-1.76). Odds ratios were adjusted for patient's age, body mass index, peak endometrial thickness, gravidity, and parity.
The current data suggest that the hCG booster given to patients within 1 day post-LH surge results in improved cycle outcomes compared to patients who do not receive the booster.
确定在自然周期冷冻胚胎移植（nFET）中，黄体期支持在 LH 峰后 1 天给予肌肉注射人绒毛膜促性腺激素（hCG）是否能提高持续妊娠率（OPR）。
回顾性队列研究纳入了 2017 年 1 月至 2018 年 12 月在学术医疗中心接受自然周期 FET 移植的女性，她们移植了一枚第 5 天或第 6 天的整倍体囊胚，这些女性被分为两组，即是否在 LH 峰后 1 天接受 hCG。排除了因子宫因素导致不孕的患者。
共纳入 529 个 nFET 周期。在控制胚胎形态等潜在混杂因素后，治疗组的 OPR 明显高于非治疗组（69.9% vs. 57.4%，p=0.0119，优势比 1.724，95%可信区间 1.13-2.65）。两组的早期流产率（优势比 1.05，95%可信区间 0.032-2.96）或生化妊娠率（优势比 0.79，95%可信区间 0.31-1.76）均无显著差异。比值比根据患者年龄、体重指数、内膜峰值厚度、孕次和产次进行了调整。
目前的数据表明，与未接受 hCG 增强剂的患者相比，LH 峰后 1 天内给予患者 hCG 增强剂可改善周期结局。
