Mäkisalo S E
Department of Orthopaedic Surgery and Traumatology, Surgical Hospital, Helsinki, Finland.
Biomaterials. 1989 Sep;10(7):499-502. doi: 10.1016/0142-9612(89)90093-8.
The capacity of three alloplastic implant materials to induce connective tissue was tested on the backs of 19 rats. A standardized viscous sponge served as control material. The commercial implant materials studied were carbon fibre and polypropylene ligament prostheses and a sponge composite of polytetrafluorethylene polymer and graphite fibre. Quantitative biochemical analyses (DNA, RNA, hydroxyproline and hexosamines) were done at 3 and 10 d, and 3, 6 and 9 wk post-operatively. Histological studies were done at 3, 6 and 9 wk. During the follow-up all the materials, when implanted subcutaneously, showed some capacity to induce ingrowth of granulation tissue. However, according to both quantitative chemical analyses and histological studies, the inductive capacity was greatest in the control sponge and in the polypropylene ligament prosthesis. In contrast, chemical analyses showed that the amount of granulation tissue developing during the follow-up was least in the rats with carbon fibre ligament implants.
在19只大鼠的背部测试了三种异体植入材料诱导结缔组织的能力。一种标准化的粘性海绵用作对照材料。所研究的商用植入材料有碳纤维和聚丙烯韧带假体，以及聚四氟乙烯聚合物与石墨纤维的海绵复合材料。在术后3天和10天以及3周、6周和9周进行了定量生化分析（DNA、RNA、羟脯氨酸和己糖胺）。在3周、6周和9周进行了组织学研究。在随访期间，所有材料皮下植入时均显示出一定的诱导肉芽组织长入的能力。然而，根据定量化学分析和组织学研究，对照海绵和聚丙烯韧带假体的诱导能力最强。相比之下，化学分析表明，在植入碳纤维韧带的大鼠中，随访期间形成的肉芽组织量最少。
