Mäkisalo S E, Paavolainen P, Grönblad M, Holmström T
Division of Orthopaedic Surgery and Traumatology, University of Helsinki, Finland.
Biomaterials. 1989 Mar;10(2):105-8. doi: 10.1016/0142-9612(89)90041-0.
The early connective tissue reactions around two alloplastic and prosthetic materials, carbon fibre and polypropylene were examined in 30 rats. Each of the materials was implanted into three sites: under the skin, intraperitoneally and into a femoral bone tunnel. Microscopic and scanning electron microscopic findings at 1, 3, 6, 9 and 12 wk post-operatively are described. The amount of granulation tissue around the carbon fibres was more prominent in all the environments, but the connective tissue remained less mature and less organized during the whole follow-up compared to that of the polypropylene. There was no ingrowth of bone between the bundles of the artificial materials in the bony tunnels. The differences in the early cellular reactions and scar tissue maturation in the interstices of these two materials are probably due to the structural differences rather than to the surface properties of the materials.
在30只大鼠中研究了两种异体塑料和假体材料（碳纤维和聚丙烯）周围的早期结缔组织反应。每种材料被植入三个部位：皮下、腹腔内和股骨骨隧道内。描述了术后1、3、6、9和12周的微观和扫描电子显微镜检查结果。在所有环境中，碳纤维周围的肉芽组织量更为显著，但与聚丙烯相比，在整个随访期间结缔组织仍不太成熟且组织性较差。在骨隧道内的人工材料束之间没有骨长入。这两种材料间隙中早期细胞反应和瘢痕组织成熟度的差异可能是由于结构差异而非材料的表面特性。
