Egorova Emiliya S, Borisova Alyona V, Mustafina Leysan J, Arkhipova Alina A, Gabbasov Rashid T, Druzhevskaya Anastasiya M, Astratenkova Irina V, Ahmetov Ildus I
a Laboratory of Molecular Genetics , Kazan State Medical University , Kazan , Russian Federation.
J Sports Sci. 2014;32(13):1286-93. doi: 10.1080/02640414.2014.898853. Epub 2014 May 1.
Research concerned with predictors of talent in football has highlighted a number of potentially important and partially inherited measures such as body size, anaerobic power, aerobic capacity, agility, psychological profile, game intelligence and susceptibility to injuries. Genotyping for performance-associated DNA polymorphisms at an early age could be useful in predicting later success in football. The aim of the study was to investigate individually and in combination the association of common gene polymorphisms with football player's status. A total of 246 Russian football players and 872 controls were genotyped for 8 gene polymorphisms, which were previously reported to be associated with athlete status. Four alleles (ACE D, ACTN3 Arg577, PPARA rs4253778 C and UCP2 55Val) were first identified, showing discrete associations with football player's status. Next, we determined the total genotype score (TGS, from the accumulated combination of the 4 polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in football players (52.0 (17.6) vs. 41.3 (15.5); P < 0.0001) than in controls. These data suggest that the likelihood of becoming a football player depends on the carriage of a high number of "favourable" gene variants.
关于足球天赋预测因素的研究突出了一些潜在重要且部分可遗传的指标，如体型、无氧能力、有氧能力、敏捷性、心理特征、比赛智商和受伤易感性。在幼年对与运动表现相关的DNA多态性进行基因分型，可能有助于预测日后在足球领域的成功。本研究的目的是单独及综合研究常见基因多态性与足球运动员身份之间的关联。对总共246名俄罗斯足球运动员和872名对照者进行了8种基因多态性的基因分型，这些多态性先前被报道与运动员身份相关。首次鉴定出四个等位基因（ACE D、ACTN3 Arg577、PPARA rs4253778 C和UCP2 55Val），它们与足球运动员身份存在离散关联。接下来，我们确定了运动员和对照者的总基因型评分（TGS，来自4种多态性的累积组合，理论上最优多基因评分的最大值为100）。足球运动员的平均TGS（52.0（17.6）对41.3（15.5）；P < 0.0001）显著高于对照者。这些数据表明，成为足球运动员的可能性取决于携带大量“有利”基因变异。
