Faculty of Health Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcon, 28223 Madrid, Spain.
Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain.
Genes (Basel). 2021 Aug 10;12(8):1230. doi: 10.3390/genes12081230.
most of the research concerning the influence of genetics on endurance performance has been carried out by investigating target genes separately. However, endurance performance is a complex trait that can stem from the interaction of several genes. The objective of this study was to compare the frequencies of polymorphisms in target genes involving cardiorespiratory functioning in elite endurance athletes vs. non-athlete controls.
genotypic frequencies were determined in 123 elite endurance athletes and in 122 non-athletes. Genotyping of (rs4340), (rs2070744 and rs1799983), (rs1800544 and rs553668), (rs1042713 and rs1042714), and BDKRB2 (rs5810761) was performed by polymerase chain reaction. The total genotype score (TGS: from 0 to 100 arbitrary units; a.u.) was calculated from the genotype score in each polymorphism.
the mean TGS in non-athletes (47.72 ± 11.29 a.u.) was similar to elite endurance athletes (46.54 ± 11.32 a.u., = 0.415). The distribution of TGS frequencies were also similar in non-athletes and elite endurance athletes ( = 0.333). There was no TGS cut-off point to discriminate being elite endurance athletes.
the genetic profile in the selected genes was similar in elite endurance athletes and in controls, suggesting that the combination of these genes does not determine endurance performance.
大多数关于遗传学对耐力表现影响的研究都是通过分别研究靶基因来进行的。然而，耐力表现是一种复杂的特征，可能源于几个基因的相互作用。本研究的目的是比较涉及心肺功能的靶基因多态性在精英耐力运动员与非运动员对照组中的频率。
对 123 名精英耐力运动员和 122 名非运动员进行基因分型频率测定。通过聚合酶链反应对 （rs4340）、 （rs2070744 和 rs1799983）、 （rs1800544 和 rs553668）、 （rs1042713 和 rs1042714）和 BDKRB2 （rs5810761）的基因型进行了检测。总基因型评分（TGS：从 0 到 100 个任意单位；a.u.）是根据每个多态性的基因型评分计算得出的。
非运动员的平均 TGS（47.72 ± 11.29 a.u.）与精英耐力运动员相似（46.54 ± 11.32 a.u.， = 0.415）。非运动员和精英耐力运动员的 TGS 频率分布也相似（ = 0.333）。没有 TGS 截断值可以区分是否为精英耐力运动员。
所选基因中的遗传特征在精英耐力运动员和对照组中相似，表明这些基因的组合并不能决定耐力表现。
