Egarter C, Fitz R, Spona J, Grünberger W, Wagenbichler P, Haidbauer R, Baumgarten K, Beck A, Leodolter S, Kiss H
I. Universitätsfrauenklinik Wien.
Geburtshilfe Frauenheilkd. 1989 Sep;49(9):808-12. doi: 10.1055/s-2008-1036090.
In this prospective multi-centre-study, the new treatment of tubal pregnancies by means of local prostaglandin (PG) F2 alpha and systemic PG E2 application was compared to the usual surgical technique of eliminating the conceptus. In 71 patients treated with PG, the method proved to be successful in 81%; 21 patients (19%) required surgical intervention later. With an initial beta-hCG level of 2500 mIE/ml, the success rate increased to 88%. The duration of hospitalisation was significantly reduced in the PG group compared to the patients treated by primary operation (3 +/- 1 versus 6 +/- 2 days). In the PG-group, only 2 of 24 hysterosalpingograms showed tubal occlusions after treatment, whereas occlusion was present in 3 of 8 patients of the surgically treated group. Four subsequent intrauterine pregnancies in the PG-group occurred compared to none in the surgical group. PG treatment of tubal pregnancy in patients with a low initial beta-hCG value (less than 2500 mIE/ml) revealed promising results with regard to reduced postoperative morbidity and future fertility.
在这项前瞻性多中心研究中，将通过局部应用前列腺素（PG）F2α和全身应用PG E2治疗输卵管妊娠的新方法与通常的清除妊娠物的手术技术进行了比较。在71例接受PG治疗的患者中，该方法被证明成功率为81%；21例患者（19%）后来需要手术干预。初始β-hCG水平为2500 mIE/ml时，成功率提高到88%。与接受初次手术治疗的患者相比，PG组的住院时间显著缩短（3±1天对6±2天）。在PG组中，24例子宫输卵管造影术后仅有2例显示输卵管阻塞，而手术治疗组的8例患者中有3例出现阻塞。PG组有4例随后发生宫内妊娠，而手术组无1例。对于初始β-hCG值较低（低于2500 mIE/ml）的输卵管妊娠患者，PG治疗在降低术后发病率和提高未来生育能力方面显示出有前景的结果。
