年龄和运动方式对女性生长激素生物活性的影响。
The influence of age and exercise modality on growth hormone bioactivity in women.
作者信息
Gordon Scott E, Kraemer William J, Looney David P, Flanagan Shawn D, Comstock Brett A, Hymer Wesley C
机构信息
Department of Kinesiology, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
出版信息
Growth Horm IGF Res. 2014 Apr-Jun;24(2-3):95-103. doi: 10.1016/j.ghir.2014.03.005. Epub 2014 Apr 8.
OBJECTIVE
Prior research has indicated that the loss of skeletal muscle mass and bone mineral density observed with aging is related to the prominent age-related decline in the concentration of serum growth hormone (GH). However, there is limited data on the effects of aging on GH responses to acute bouts of heavy resistance exercise (HRE) and aerobic exercise (AE).
DESIGN
The present investigation examined the effects of a HRE protocol and an AE protocol on immunoreactive GH (IGH) and bioactive GH (BGH) in active young and old women.
RESULTS
Older women had a diminished serum IGH response to both the HRE and AE protocols compared to the younger women, however a similar response was not observed in serum BGH. Additionally, the HRE protocol elicited a greater BGH response than the AE protocol exclusively in the younger group.
CONCLUSIONS
Regardless of exercise mode, aging induces an increase in growth hormone polymerization that specifically results in a loss of serum growth hormone immunoreactivity without a concurrent loss of serum growth hormone bioactivity. The greater BGH response to the HRE protocol found in the younger group can be attributed to an unknown serum factor of molecular weight between 30 and 55kD that either potentiated growth hormone bioactivity in response to HRE or inhibited growth hormone bioactivity in response to AE.
目的
先前的研究表明，随着年龄增长观察到的骨骼肌质量和骨矿物质密度的丧失与血清生长激素（GH）浓度显著的年龄相关性下降有关。然而，关于衰老对GH对急性大强度抗阻运动（HRE）和有氧运动（AE）反应的影响的数据有限。
设计
本研究调查了HRE方案和AE方案对活跃的年轻和老年女性中免疫反应性GH（IGH）和生物活性GH（BGH）的影响。
结果
与年轻女性相比，老年女性对HRE和AE方案的血清IGH反应均减弱，然而血清BGH未观察到类似反应。此外，仅在年轻组中，HRE方案引发的BGH反应比AE方案更大。
结论
无论运动方式如何，衰老都会导致生长激素聚合增加，这具体导致血清生长激素免疫反应性丧失，而血清生长激素生物活性不会同时丧失。在年轻组中发现的对HRE方案更大的BGH反应可归因于分子量在30至55kD之间的未知血清因子，该因子要么增强了对HRE的生长激素生物活性，要么抑制了对AE的生长激素生物活性。
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