Kraemer W J, Häkkinen K, Newton R U, McCormick M, Nindl B C, Volek J S, Gotshalk L A, Fleck S J, Campbell W W, Gordon S E, Farrell P A, Evans W J
Noll Physiological Research Center and Laboratory for Sports Medicine, Pennsylvania State University, University Park 16802, USA.
Eur J Appl Physiol Occup Physiol. 1998 Feb;77(3):206-11. doi: 10.1007/s004210050323.
The purpose of this investigation was to examine the acute responses of several hormones [total and free testosterone (TT and FT, respectively), adrenocorticotropic hormone (ACTH), cortisol (C), growth hormone (GH), and insulin (INS)] to a single bout of heavy resistance exercise (HRE). Eight younger [30-year (30y) group] and nine older [62-year (62y) group] men matched for general physical characteristics and activity levels performed four sets of ten repetitions maximum (RM) squats with 90 s rest between sets. Blood samples were obtained from each subject via an indwelling cannula with a saline lock pre-exercise, immediately post-exercise (IP), and 5, 15 and 30 min post-exercise. Levels of TT, FT, ACTH, C and lactate significantly increased after HRE for both groups. Pre-HRE pairwise differences between groups were noted only for FT, while post-HRE pairwise differences were found for TT, FT, GH, glucose and lactate. Area under the curve analysis showed that the 30y group had a significantly higher magnitude of increase over the entire recovery period (IP, 5, 15, and 30 min post-exercise) for TT, FT, ACTH and GH. Few changes occurred in the INS response with the only change being that the 62y group demonstrated a decrease IP. Lactate remained elevated at 30 min post-HRE. This investigation demonstrates that age-related differences occur in the endocrine response to HRE, and the most striking changes appear evident in the FT response to HRE in physically active young and older men.
本研究的目的是检测几种激素[总睾酮和游离睾酮（分别为TT和FT）、促肾上腺皮质激素（ACTH）、皮质醇（C）、生长激素（GH）和胰岛素（INS）]对单次大强度抗阻运动（HRE）的急性反应。八名较年轻男性[30岁（30y）组]和九名较年长男性[62岁（62y）组]，他们在一般身体特征和活动水平方面相匹配，进行了四组每组10次最大重复次数（RM）的深蹲练习，组间休息90秒。在运动前、运动后即刻（IP）以及运动后5、15和30分钟，通过带有生理盐水锁的留置套管从每个受试者采集血样。两组在HRE后TT、FT、ACTH、C和乳酸水平均显著升高。组间在HRE前仅FT存在两两差异，而在HRE后TT、FT、GH、葡萄糖和乳酸均存在两两差异。曲线下面积分析显示，30y组在整个恢复期间（运动后IP、5、15和30分钟）TT、FT、ACTH和GH的升高幅度显著更高。INS反应几乎没有变化，唯一的变化是62y组在IP时出现下降。HRE后30分钟乳酸仍保持升高。本研究表明，在对HRE的内分泌反应中存在年龄相关差异，在身体活跃的年轻和年长男性中，对HRE的FT反应中出现的变化最为显著。
