Dahinden C A, Kurimoto Y, De Weck A L, Lindley I, Dewald B, Baggiolini M
Institute of Clinical Immunology, University of Bern, Switzerland.
J Exp Med. 1989 Nov 1;170(5):1787-92. doi: 10.1084/jem.170.5.1787.
IgE-independent mediator release from basophils is considered an important event in inflammation, particularly in nonallergic immediate hypersensitivity and in allergic late-phase reactions. This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1. Thus, the sequential action of two pure cytokines can promote basophils mediator release. In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions.
嗜碱性粒细胞释放不依赖IgE的介质被认为是炎症中的一个重要事件，特别是在非过敏性速发型超敏反应和过敏性迟发相反应中。本研究表明，在暴露于IL-3后，嗜碱性粒细胞会响应中性粒细胞激活肽NAF/NAP-1释放组胺和白三烯。因此，两种纯细胞因子的序贯作用可促进嗜碱性粒细胞介质释放。在IL-3存在的情况下，NAF/NAP-1的作用类似于“组胺释放因子”，因此不仅可能诱导细胞浸润，还可能引发超敏反应症状。
