Kimata H, Lindley I
Department of Paediatrics, Kyoto University Hospital, Japan.
Arch Dis Child. 1994 Feb;70(2):119-22. doi: 10.1136/adc.70.2.119.
Plasma interleukin-8 (IL-8) concentrations were measured in patients with atopic dermatitis. Plasma IL-8 was not detected in 25 controls (0/25), in allergic rhinitis (0/20), or in bronchial asthma during remission (0/13), while low concentrations of IL-8 were detectable in a few patients with urticaria (1/19), contact dermatitis (4/17), and bronchial asthma at the time of attack (6/16). In contrast, IL-8 was detectable in most cases of atopic dermatitis (41/52). Moreover, IL-8 concentrations were significantly higher in severe than in mild or moderate atopic dermatitis. IL-8 concentrations decreased as atopic dermatitis was improved by treatment, and IgE production in vitro was also decreased while serum IgE concentrations remained unchanged. IL-8 measurement may be a useful tool for the study of the pathogenesis and clinical course of atopic dermatitis.
对特应性皮炎患者的血浆白细胞介素-8(IL-8)浓度进行了测定。在25名对照者(0/25)、变应性鼻炎患者(0/20)或支气管哮喘缓解期患者(0/13)中未检测到血浆IL-8,而在少数荨麻疹患者(1/19)、接触性皮炎患者(4/17)和支气管哮喘发作期患者(6/16)中可检测到低浓度的IL-8。相比之下,在大多数特应性皮炎病例(41/52)中可检测到IL-8。此外,重度特应性皮炎患者的IL-8浓度显著高于轻度或中度患者。随着特应性皮炎经治疗改善,IL-8浓度降低,体外IgE产生也减少,而血清IgE浓度保持不变。检测IL-8可能是研究特应性皮炎发病机制和临床病程的有用工具。