Clark Kathleen A, Graves Barbara J
Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA;
Genes Dev. 2014 May 1;28(9):926-8. doi: 10.1101/gad.242420.114.
Esnault and colleagues (pp. 943-958) take a genomics approach to investigate the role of SRF (serum response factor) in the serum response of fibroblasts. The well-established dual role of SRF with alternative cofactors and responsiveness to two signaling pathways is illustrated at the genome-wide level, yet new insight comes from this global picture.
埃斯诺及其同事(第943 - 958页)采用基因组学方法来研究血清反应因子(SRF)在成纤维细胞血清反应中的作用。SRF与不同辅助因子的既定双重作用以及对两条信号通路的反应性在全基因组水平上得到了阐释,但这一全局图景也带来了新的见解。