Department of Microbiology, Faculty of Medicine, Chiang Mai University, 110 Intawarorose, Sriphoom, Muang, Chiang Mai, 50200, Thailand.
Arch Virol. 2014 Sep;159(9):2485-9. doi: 10.1007/s00705-014-2091-6. Epub 2014 May 1.
Human cosavirus (HCoSV) is a newly discovered virus of the family Picornaviridae. A total of 411 fecal specimens were collected from children admitted to hospitals with acute gastroenteritis symptoms in Chiang Mai, Thailand, in 2010-2011 and screened for HCoSV by an RT-nested PCR method. HCoSV was found in a single specimen (CMH-N199-11) collected from a 3-year-old boy. This represents the first report of HCoSV infection in a pediatric patient with diarrhea in Thailand. Analysis of the complete coding sequence revealed that this HCoSV was most similar to the Chinese HCoSV-A reference strain SH1, and belonged to genotype A6. The data imply that HCoSVs detected in Thailand and China share the same evolutionary ancestor. Our results emphasize the need for further research to understand the distribution, genetic diversity, and association of the HCoSV with acute gastroenteritis in humans.
人杯状病毒（HCoSV）是杯状病毒科的一种新发现的病毒。2010 年至 2011 年，从泰国清迈因急性肠胃炎症状住院的儿童中采集了 411 份粪便标本，采用 RT-巢式 PCR 方法对 HCoSV 进行筛查。在从一名 3 岁男孩采集的单一标本（CMH-N199-11）中发现了 HCoSV。这是泰国首例儿童腹泻患者感染 HCoSV 的报告。对完整编码序列的分析表明，这种 HCoSV 与中国的 HCoSV-A 参考株 SH1 最为相似，属于基因型 A6。这些数据表明，在泰国和中国检测到的 HCoSV 具有相同的进化祖先。我们的研究结果强调需要进一步研究以了解 HCoSV 在人类中与急性肠胃炎的分布、遗传多样性和关联。
