Okitsu Shoko, Khamrin Pattara, Hanaoka Nozomu, Thongprachum Aksara, Takanashi Sayaka, Fujimoto Tsuguto, Mizuguchi Masashi, Shimizu Hiroyuki, Hayakawa Satoshi, Maneekarn Niwat, Ushijima Hiroshi
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1, Oyaguchi-kamicho, Itabashi, Tokyo, 173-8610, Japan.
Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Arch Virol. 2016 Jan;161(1):159-63. doi: 10.1007/s00705-015-2637-2. Epub 2015 Oct 14.
Cosavirus is a recently established genus in the family Picornaviridae. The present study investigated the prevalence and genetic diversity of cosaviruses in stool samples collected from piglets and pigs with and without diarrhea in Thailand and Japan. It was observed that the cosavirus-positive rate in Thailand was higher than in Japan (55.4 % vs. 18.9 %). Phylogenetic analysis of a portion of the 5' untranslated region showed that porcine cosavirus strains clustered together in the same branch with members of the species Cosavirus A. These strains showed 97.0 to 100 % nucleotide sequence identity to each other. The virus concentration of cosavirus was very low compared with that detected in a infant with diarrhea. These results demonstrated that cosaviruses were circulating in the swine populations of both countries during the study term; however, it remains unclear whether the virus causes diarrhea in piglets and pigs.
柯萨病毒是小RNA病毒科中一个最近确定的属。本研究调查了泰国和日本有腹泻和无腹泻的仔猪及猪粪便样本中柯萨病毒的流行情况和遗传多样性。结果发现，泰国柯萨病毒阳性率高于日本（55.4%对18.9%）。对5'非翻译区部分序列的系统发育分析表明，猪源柯萨病毒株与柯萨病毒A种的成员聚集在同一分支。这些毒株彼此间核苷酸序列同一性为97.0%至100%。与在一名腹泻婴儿中检测到的病毒浓度相比，柯萨病毒的病毒浓度非常低。这些结果表明，在研究期间，柯萨病毒在两国的猪群中传播；然而，该病毒是否导致仔猪和猪腹泻仍不清楚。
