地笋素A - E，从粘毛地笋中分离得到的五种新的新克罗烷二萜类化合物。
Teucvisins A-E, five new neo-clerodane diterpenes from Teucrium viscidum.
作者信息
Lv Hua-wei, Luo Jian-guang, Zhu Meng-di, Shan Si-ming, Kong Ling-yi
机构信息
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University.
出版信息
Chem Pharm Bull (Tokyo). 2014;62(5):472-6. doi: 10.1248/cpb.c13-00990.
Two new neo-clerodane diterpenoids, teucvisins A and B (1, 2), and three new 19-nor-neoclerodane diterpenoids, teucvisins C-E (3-5), together with ten known constituents (6-15) were isolated from the whole plants of Teucrium viscidum. All the isolates were evaluated for their inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages. The results indicated that compounds 11 and 15 showed moderate inhibition with an IC50 value of 21.9 and 22.4 µM, respectively.
从粘毛香科植物全草中分离得到两个新的新克罗烷二萜类化合物，teucvisins A和B（1, 2），以及三个新的19-降新克罗烷二萜类化合物，teucvisins C - E（3 - 5），同时还分离得到了十个已知成分（6 - 15）。对所有分离得到的化合物进行了脂多糖（LPS）诱导RAW264.7巨噬细胞产生一氧化氮的抑制活性评估。结果表明，化合物11和15表现出中等程度的抑制作用，IC50值分别为21.9和22.4 μM。
Zotero 插件