Alvarez C, García J F, López M A
Departamento de Fisiología y Farmacología, Facultad de Biología, Universidad de Salamanca, Spain.
Pancreas. 1989;4(5):543-9. doi: 10.1097/00006676-198910000-00004.
The effects of a copper-deficient diet supplemented with D-penicillamine on both the structure and exocrine function of the pancreas were studied in rabbits. The pancreases of the animals kept on this diet for 13 weeks showed lesions in the acinar tissue but not in ductal or islet tissue. The weights of the glands were markedly reduced. Copper deficiency caused a slight (non-significant) reduction in the flow of pancreatic juice and in sodium output and significantly decreased chloride output (p less than 0.01). No changes were observed in bicarbonate and potassium output. Total protein and amylase secretions were maintained at clearly detectable levels in pancreatic juice, although they decreased significantly (p less than 0.01 and p less than 0.001, respectively), in the copper-deficient animals compared with the controls. The pancreases of the animals kept on a copper-deficient diet were seen to maintain their capacity for response to secretin, cholecystokinin (CCK), and bethanechol. Our results show that rabbit pancreatic acinar tissue is less sensitive to copper deficiency than that of other species studied. Additionally, the data on secretion of water and electrolytes suggest that in the rabbit the acinar cells may contribute to the secretory process with a chloride-rich fluid.
研究了在缺铜饮食中补充D-青霉胺对家兔胰腺结构和外分泌功能的影响。持续13周食用这种饮食的动物的胰腺，腺泡组织出现病变，但导管或胰岛组织未出现病变。腺体重量显著减轻。缺铜导致胰液分泌量和钠排出量略有（无统计学意义）减少，而氯排出量显著降低（p<0.01）。碳酸氢盐和钾的排出量未观察到变化。尽管与对照组相比，缺铜动物胰液中的总蛋白和淀粉酶分泌量显著降低（分别为p<0.01和p<0.001），但仍维持在可明显检测到的水平。观察到持续食用缺铜饮食的动物的胰腺保持了对促胰液素、胆囊收缩素（CCK）和氨甲酰甲胆碱的反应能力。我们的结果表明，家兔胰腺腺泡组织对缺铜的敏感性低于其他已研究的物种。此外，关于水和电解质分泌的数据表明，在家兔中，腺泡细胞可能通过分泌富含氯的液体来参与分泌过程。
