Alvarez C, López M A
Departamento de Fisiologia y Farmacologia, Facultad de Biologia, Universidad de Salamanca, Spain.
Int J Pancreatol. 1989 Oct;5(3):229-38. doi: 10.1007/BF02924468.
The influence of the endocrine pancreas on the exocrine pancreatic secretion of both electrolytes and enzymes was studied in rabbits made diabetic by alloxan administration. No alterations were observed in the flow of pancreatic juice. Bicarbonate concentrations were considerably increased, whereas chloride concentrations were clearly reduced in the alloxan-diabetic rabbits compared with the control animals. Insulin treatment restored anion levels to normal. Similar, although less pronounced changes were seen in the output values of bicarbonate and chloride. There were no significant differences between the control and alloxan-treated animals in the output of sodium and potassium; however, potassium concentrations exhibited a significant rise both in untreated and insulin-treated diabetic rabbits compared with the controls. Total protein and amylase secretion decreased markedly in the diabetic animals. The secretion of amylase was not brought back to control values by additional administration of insulin. These results suggest that the endocrine pancreas plays an extremely important role in exocrine pancreatic function.
通过给兔子注射四氧嘧啶使其患糖尿病，研究内分泌胰腺对外分泌胰腺电解质和酶分泌的影响。未观察到胰液分泌量有变化。与对照动物相比，四氧嘧啶糖尿病兔的碳酸氢盐浓度显著升高，而氯浓度明显降低。胰岛素治疗可使阴离子水平恢复正常。碳酸氢盐和氯的输出值也有类似变化，不过不太明显。对照动物和接受四氧嘧啶治疗的动物在钠和钾的输出方面没有显著差异；然而，与对照组相比，未经治疗和接受胰岛素治疗的糖尿病兔的钾浓度均显著升高。糖尿病动物的总蛋白和淀粉酶分泌明显减少。额外注射胰岛素并未使淀粉酶分泌恢复到对照值。这些结果表明，内分泌胰腺在外分泌胰腺功能中起着极其重要的作用。
