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基于协同神经网络的两段式外显子识别模型。

A two-stage exon recognition model based on synergetic neural network.

机构信息

School of Mathematics Sciences, Huaqiao University, Quanzhou 362021, China ; Cognitive Science Department, Xiamen University, Xiamen 361005, China.

Cognitive Science Department, Xiamen University, Xiamen 361005, China ; Fujian Key Laboratory of the Brain-Like Intelligent Systems, Xiamen 361005, China.

出版信息

Comput Math Methods Med. 2014;2014:503132. doi: 10.1155/2014/503132. Epub 2014 Mar 25.

Abstract

Exon recognition is a fundamental task in bioinformatics to identify the exons of DNA sequence. Currently, exon recognition algorithms based on digital signal processing techniques have been widely used. Unfortunately, these methods require many calculations, resulting in low recognition efficiency. In order to overcome this limitation, a two-stage exon recognition model is proposed and implemented in this paper. There are three main works. Firstly, we use synergetic neural network to rapidly determine initial exon intervals. Secondly, adaptive sliding window is used to accurately discriminate the final exon intervals. Finally, parameter optimization based on artificial fish swarm algorithm is used to determine different species thresholds and corresponding adjustment parameters of adaptive windows. Experimental results show that the proposed model has better performance for exon recognition and provides a practical solution and a promising future for other recognition tasks.

摘要

外显子识别是生物信息学中的一项基本任务,用于识别 DNA 序列的外显子。目前,基于数字信号处理技术的外显子识别算法已经得到了广泛的应用。然而,这些方法需要大量的计算,导致识别效率低下。为了克服这一限制,本文提出并实现了一种两阶段的外显子识别模型。主要有三项工作。首先,我们使用协同神经网络快速确定初始外显子区间。其次,自适应滑动窗口用于准确判别最终的外显子区间。最后,基于人工鱼群算法进行参数优化,确定不同物种的阈值和自适应窗口的相应调整参数。实验结果表明,所提出的模型在外显子识别方面具有更好的性能,为其他识别任务提供了一种实用的解决方案和广阔的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/3984832/73f4fa85c711/CMMM2014-503132.001.jpg

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